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I find interesting the different dosing of medicine. I am glad when others (and their doctors) have found the dosing that works for them. Retha, my wife, has been taking Mirapex for some time now. She was taking 2mg/4time/day and now is taking 1.5mg/4time/day and carbadoba/levadopa 1/2 tab 4xdaily. She tells me often that she finds herself waking up around 3 am for a while and trying to go back to sleep. Sleep is important for her, because she still works full time 5 days a week as a custodian. Her bosses are helpful and understanding. Her doctors also think it better to keep working as long as she is able. This should help keep her mobile and, hopefully, less stiff or rigid. Seems to be working that way so far. Hoping this helps someone, even just a little. George (husband of and caregiver for Retha 50/47/43) ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn