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In conjunction with Lockheed Martin Corporation and NIH, doctors at the Johns Hopkins University School of Medicine are seeking volunteer patients with Parkinson's disease (PD) who experience "freezing" or start hesitation to participate in a clinical trial to assess the effects of a physical device on the motor symptoms of PD. Volunteers are needed for a clinical trial to test whether a device, referred to as a Transcutaneous Electrical Movement Timing Stimulator (TEMTS), improves the motor symptoms of Parkinson's disease (PD), including bradykinesia (slowed movements), akinesia (inability to initiate movements), rigidity, and tremor. The TEMTS device was modeled after a transcutaneous electrical nerve stimulation (TENS) unit, a safe and commonly used device to treat pain symptoms. The TEMTS used in this trial is a lightweight portable battery-operated machine (<2 pounds) that is inserted into a pouch attached to a belt and worn around the waist. The device provides alternating pulses of low-level stimulation to cutaneous electrodes that are placed on the skin over a given extremity according to the task performed, e.g., over the forearm and wrist for typing movements. The purpose of this clinical trial is to test the effects of the TEMTS device on quantified measures of motor initiation, speed, tremor, and tone. This clinical trial will be limited to patients who experience disruptive slowness of movement or difficulty initiating movements (also known as "freezing" or start hesitation). In addition, participants must be over age 20 (male or female), have a diagnosis of mild to moderately severe PD (Hoehn and Yahr stage II-IV), be on a stable regimen of antiparkinsonian medications, and not experience disabling memory impairment. Subjects with a pacemaker or brain-stimulating device are not eligible for the study. The study will take place at Johns Hopkins Hospital and will require about 4 hours of testing. The testing can take place over two separate days. Participants will be provided free parking and compensated $20 for their time and the costs of traveling to Johns Hopkins. If you are interested in participating, please contact Melissa Gerstenhaber, R.N., M.S.N., Research Nurse Coordinator for the Morris K. Udall Parkinson's Disease Research Center of Excellence at Johns Hopkins (410-614-1242) or email her at [log in to unmask] The principal investigator of this study is Laura Marsh, M.D.. Lockheed Martin Corporation and the National Institutes of Health are providing financial support for the study. ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn