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hi all 'normalizing receptor function' 'correct side effects' - this kind of new news warms the cockles of my heart! if levodopa minimizes my pd symptoms and if i didn't get side effects from taking levodopa how would i even know i had pd? and here's more proof as if we need it that managing pd longterm is a matter of finer and finer tuning - put that sledgehammer away! janet ----------------------------------------------------- Attenuation of levodopa-induced dyskinesia by normalizing dopamine D(3) receptor function. In monkeys rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), expression of the dopamine D(3) receptor was decreased. However, levodopa-induced dyskinesia (LID), similar to the debilitating and pharmaco-resistant involuntary movements elicited after long-term treatment with levodopa in patients with Parkinson disease (PD), was associated with overexpression of this receptor. Administration of a D(3) receptor-selective partial agonist strongly attenuated levodopa-induced dyskinesia, but left unaffected the therapeutic effect of levodopa. In contrast, attenuation of dyskinesia by D(3) receptor antagonists was accompanied by the reappearance of PD-like symptoms. These results indicated that the D(3) receptor participated in both dyskinesia and the therapeutic action of levodopa, and that partial agonists may normalize D(3) receptor function and correct side effects of levodopa therapy in patients with PD. Nat Med 2003 May 12; Bezard E, Ferry S, Mach U, et al Basal Gang, Laboratoire de Neurophysiologie, 33076 Bordeaux, France. PMID: 12740572 ----------------------------------------------------- janet paterson: an akinetic rigid subtype, albeit primarily perky, parky pd: 56-41-37 cd: 56-44-43 tel: 613-256-8340 email: [log in to unmask] my newsletter: http://groups.yahoo.com/group/newvoicenews/ my website: http://www.geocities.com/janet313/ ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn