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I'm one of those who presented with depression--the apathetic variety--at my initial diagnostic examination with a neurologist. For what it's worth, Paxil didn't do a thing for me either, but Zoloft did when I went up to 100mg. I started at 50, and I believe I went to 75, and then 100. I have definately heard from more than a couple of people that Paxil didn't work for them. I found it easy to gradually decrease one and move to another without any adverse events. From what you wrote, I agree that it's time to try another, and I'm pretty sure that you will find one that gives you good relief. Prozac worked for me also, but the doctors seem to have moved away from that. I've tried one or two others, but Zoloft seems to work best for me. I have not tried Wellbutrin(?), and kind of wished I had. Tried Effexor and can't remember the reason why I didn't stick with that. Good luck. Charlotte Mancuso They all are SSRIs, but they are not the same compounds, and, as with other drugs, it's a very individual kind of thing--I hear over and over again from other people with and without PD, that a particular one worked and another didn't. But then the different dosages matter also. Tom McCreary <[log in to unmask]> wrote:I have been on 40mg Paxil for almost 1 year, up from 20 which I have taken for almost years. I haven't noticed any improvement other than the depression is more obvious. I am ready for a new anti-depressant that will take the "blues away". I am self-employed without much pressure but it gets to be overwhelming at times. I do have a lot of decisions to make and I worry about my wife having to assume more of the daily responsibilities as months march by. And the ever present financial concerns, etc. Is there any practical next drug to request or avoid. What is the best way to come off one and begin the next drug? What are likely Reponses to this change? ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn Tom the mini-tremorer