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I cannot speak to the long term effects of Sinment beyond 5 years. I will say that if you are very active and are very careful with the medicine and not take more than absolutely necessary you can stretch out the onset of side effects for several years. I unfortunately became over medicated before I should have. With more knowledge I have cut back about 25%. A 100/250 CR dose peaks in 3 or 4 hours. If you work out a fairly tight schedule of medication and meals, you can have a decent work day. I think the balance is between current function and future problems which may or may not be that bad. Still, your doctor is right to be cautious. Regards, Bill Lawless [Post hoc, ergo propter hoc!] a logical fallacy. ----- Original Message ----- From: Roberta Innarella To: [log in to unmask] Sent: Sunday, June 08, 2003 8:24 PM Subject: Re: Paula from PA Bob, yes my doctor does not want to give me Sinmet because of the inevitable (supposedly) side effects. Don't know much about taking Comtan anad Sinemet together. Yes, I'm still working. I am on my own and need to keep working as long as I can but when you're a secretary and your left hand is uncooperative while typing, it's difficult. I would love to find some relief from my symptoms (other than sleeping). Have tried Amantadine, Mirapex, Artane, Requip, Eldepryl. Amantadine and Artane twice. I'm running out of options. Don't know what to do. Roberta ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn