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I can speak to the somewhat longer term effects of Sineme I was dxed 9 years ago and, as was done in that long-ago age, was prescribed sinemet 25/100 3x/day (as well as 5 mg. eldepryl 2x/day.) I later learned that I could have gotten by --and done pretty well--without sinemet so early but I found it impossible to do without it, at that point so I set out to cut down the dosage. 5 years later I was down to half that dosage (combined with amantadine, mirapex and permax) but even that began to give me unacceptable levels of dyskinesia. Now, I have worked out my own regimen that my neurologist knows about, but is not in wholehearted approval (because of the complexity of the regimen.) I take the same amount of Sinemet I was taking 4 years ago (2 and 1/2 tablets of 25/100 each day), but I divide each half-tablet in half again (by biting it--its too small to cut) and take those about 1 and 1/2 hours apart. It seems to keep the dyskinesia at bay and the day goes pretty smoothly. There are times when I fel the need to take the full 1/2 tablet of Sinemet (when I am about to exercise or work in the garden) but usually not. It works for me! Nancy deG Bill Lawless wrote: >I cannot speak to the long term effects of Sinment beyond 5 years. I will say that if you are very active and are very careful with the medicine and not take more than absolutely necessary you can stretch out the onset of side effects for several years. I unfortunately became over medicated before I should have. With more knowledge I have cut back about 25%. A 100/250 CR dose peaks in 3 or 4 hours. If you work out a fairly tight schedule of medication and meals, you can have a decent work day. I think the balance is between current function and future problems which may or may not be that bad. Still, your doctor is right to be cautious. > > Regards, Bill Lawless >[Post hoc, ergo propter hoc!] a logical fallacy. > > > >----- Original Message ----- > From: Roberta Innarella > To: [log in to unmask] > Sent: Sunday, June 08, 2003 8:24 PM > Subject: Re: Paula from PA > > > Bob, yes my doctor does not want to give me Sinmet because of the inevitable > (supposedly) side effects. Don't know much about taking Comtan anad Sinemet > together. Yes, I'm still working. I am on my own and need to keep working as > long as I can but when you're a secretary and your left hand is uncooperative > while typing, it's difficult. I would love to find some relief from my > symptoms (other than sleeping). Have tried Amantadine, Mirapex, Artane, Requip, > Eldepryl. Amantadine and Artane twice. I'm running out of options. Don't know > what to do. Roberta > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > >---------------------------------------------------------------------- >To sign-off Parkinsn send a message to: mailto:[log in to unmask] >In the body of the message put: signoff parkinsn > > > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn