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The Scientist Daily News
July 17, 2003

Stem cell forum launched
Twelve nations sign up for project designed to speed up research
By Pat Hagan

Scientists from 12 countries have officially launched a new organization designed to promote collaboration on stem cell
research and to speed up the development of new medical treatments.

Called the International Stem Cell Forum, the new body was sanctioned at a meeting chaired by the UK's Medical Research
Council (MRC) in London on July 11. The launch comes just 6 months after the MRC announced it was setting up an
informal discussion forum to tackle stem cell research on a global rather than national basis.

The main aim is to produce international scientific benchmarks on the characteristics of new and existing stem cell
lines. This will be achieved by inviting researchers from major institutions in each of the member countries to examine
cell lines, using standardized tools and procedures.

Apart from the UK representatives, signatories include the US National Institutes of Health, the National Health and
Medical Research Council of Australia, the Canadian Institutes of Health Research, and the Israel Academy of Sciences
and Humanities. The other states involved in the collaboration are Germany, France, Japan, Finland, Singapore, the
Netherlands, and Sweden.

A new registry of stem cell lines, which will be made available on a dedicated Web site, is being developed under the
leadership of Peter Andrews from the Centre for Stem Cell Biology at the University of Sheffield.

One of the underlying concerns has been that in the race to explore new applications for stem cell technology, teams of
scientists around the world could end up working to different criteria or duplicating one another's efforts.

The idea behind the forum is to reduce this as much as possible and to speed up research by sharing information. The
United Kingdom will take charge of the drive to characterize cell lines, and representatives from Australia and Canada
have agreed to explore ethical and patenting issues.

MRC Chief Executive George Radda said in a press statement: "International coordination will accelerate progress in
this cutting-edge area of research, maximizing health benefits for the global public."

James Battey from the US National Institutes of Health said he hoped the initiative would allow US scientists to
"harmonize" their research efforts with those elsewhere.

He told The Scientist, "A standardized approach to characterizing human embryonic stem cell lines throughout the
international research community will reveal similarities and differences between the properties and potential of lines
established at different times under different experimental protocols. Such an effort will undoubtedly accelerate the
pace of discovery."

According to Andrews, a "task force" of four or five representatives has been formed to establish a program of work for
the forum for the next year.

"We'll do it in bite-sized chunks because it's such a huge project," he told The Scientist. "It's a question of working
on the key parts, such as how to characterize cell lines, how to stop them doing things you don't want them to do, and
how to get them to differentiate into cells that you want.

"There is a huge amount of promise in stem cell research but also a huge amount of hype, so we have to be careful what
we tell people. It could take 15 to 20 years, but there's a good chance we could produce therapies that are really
revolutionary for diseases that cripple a lot of people," said Andrews.
Links for this article
Medical Research Council
http://www.mrc.ac.uk/

T. Agres, "Coming clean on stem cells," The Scientist, January 21, 2003.
http://www.biomedcentral.com/news/20030121/04/

P. Hagan, "Stem cell collaboration," The Scientist, June 2, 2003.
http://www.biomedcentral.com/news/20030602/02/

National Institutes of Health
http://www.nih.gov/

National Health and Medical Research Council
http://www.health.gov.au/nhmrc/

Canadian Institutes of Health Research
http://www.cihr-irsc.gc.ca/

Israel Academy of Sciences and Humanities
http://www.academy.ac.il/

Peter Andrews
http://www.shef.ac.uk/bms/academic/pwa.html

Centre for Stem Cell Biology
http://www.shef.ac.uk/stemcell/

A. Scott, "Guidelines for EU funding of stem cell research," The Scientist, July 10, 2003.
http://www.biomedcentral.com/news/20030710/04/

SOURCE:  The Scientist Daily News
http://www.biomedcentral.com/news/20030717/04

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