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Hi Tom, I have no solutions... I also take Sinemet, Sinemet CR, and Comtan... I also can't sleep... This preceded Comtan completely... so I would tend to rule out Comtan as the culprit... A little background... I never seemed to require much sleep but had no problem sleeping for 4 - 6 hours all my life... Since the onset of Parkinson's I have difficulty sleeping at all and seldom get more than 2 uninterrupted hours or more than 4 hours per night... Difficulty sleeping preceded meds but has gotten musch worse since... Is it Sinemet? Parkinson's? I have no answer... Good luck and keep us posted... cheers ..... murray * * * On 21 Jul 2003 at 0:38, Tom McCreary wrote: I cant sleep. After seeing a new nuero out of necesssity my drugs have been changed. 6 year old regimen of : 1 Sinemet 25/100 1xday, 1 Symmetryl 1x/day, 1 Eldepryl 1x/day, 1 sinemet 25/100 CR and Mirapex 3xs/day ... modified to: 1 sinemt 25/100 with 1 Comptan 3x/day, and 1Mirapex 3 xs/day.... Result = Offs were very bothhersome so I initiated all 3 at smae time anad got a little betteer performacnne. Next visit was in 3 weeks which was last Thursday My offs still were comng too quick and too debilitating. So new Dr droppped Mirapex and added 1/2 tab more Sinemet 25/100 resulting in good ons but offs were still unacceptable appeariing at 3 hours into 4 four dosage schedule So I dropped the 1/2 dose of Sinemet and added back in 1 Sinemet CR 25/100 with hopes of reducing off time by increasaing on. This has given a more workable on tine frame. Here is the problem. The second night or last Friday i didnt sleep. All was fine until bed time. WHen i became still a guick tensiioning of an isolated muscle group producing something of a tiny explosive jerk reactiion began occurring and very persistent. When i got up it wouldnt occurr but when relaxed it would reappear. Sometimes in new areas. Saturuday was fine Staurdady night Hell night 2. Sundday was fair and tonight sassme thing is occuring. Have I decended to anoother level of PD. What might tomorrow bring? More worrysome is tomorrow night?. The new DR isnt available on weekends but her answeirng machine is on duty. I will be calling with my concerns. If you have made it this far i would like some relative coments if you have any. * * * Murray Charters <[log in to unmask]> http://www.geocities.com/murraycharters/ ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn