See this folks :
Marijuana receptor agonist reduces levodopa-induced diskinesias
/*Nabilone effective in an animal model of Parkinson’s disease*/
/(Tuesday, 11 March 2003)/
In an animal model of Parkinson’s disease, in which the disease was
produced by the administration of the toxin MPTP, the co-administration
of nabilone, an agonist i.e. stimulant of cannabinoid receptors, was
associated with halving of dyskinesias (involuntary movements) without
any reduction in the therapeutic effects of levodopa on motor function.
On the contrary, nabilone actually prolonged the effect of levodopa by
76%. Cannabinoid receptors are the receptors for marijuana, called also
cannabis; they are concentrated mainly in the basal ganglia of the
brain, which control movement. Cannabinoid receptor agonists could be a
novel approach to motor complications induced by dopaminergic therapy in
Parkinson’s disease.
Fox et al. Mov Disord 2002; 17: 1180-1187
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Cheers,
Joao Carvalho
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