the pallidotomy marginally helped a lot of things. It not only got rid of the hellish dyskinesia. Since my PVP I dfont have Migrains any more I bagan sleeping all night, I was able to drive again,my PD medications started to work again they hadn't been working David Moreland --- "Nancy S. deGrazia" <[log in to unmask]> wrote: > David - that's good to hear. Were your PD symptoms > across the board > (tremor, gait problems, freezing, etc)? And which > ones did the > pallidotomy help? > > Nancy deG > > David Moreland wrote: > > >--- "Nancy S. deGrazia" <[log in to unmask]> > >wrote: > > > > > >>Thank you, Chris : > >>No. my "end of dose " phenomenom is the onset of > >>dyskinesia. I seem to > >>have both "peak dose" and "end of dose" > dyskinesia. > >>I have been taking > >>sinemet for almost 10 years and over that period > >>have added eldepryl, > >>permax, mirapex and amantadine. I guess the reason > I > >>am taking so many > >>different things is that I am hypersensitive to > >>levadopa. I take 1/4 of > >>a 25/100 every 90 minutes and if I take more the > >>dyskinesia is just awful.. > >> > >>Anyone else with this kind of problem? > >>I used to have diskinesias that on a 1 to 10 > >> > >> > >scale mine were up to 13 or 14 . Then i had a > >pallidototomy. For the most part I have been free > of > >dyskinesia since then (1995} > >David Moreland > > > > > >>Nancy deG > >> > >>Chris Lui wrote: > >> > >> > >> > >>>Hi Nancy: > >>> > >>>My end of dose phenomenon refers to premature > >>> > >>> > >>ending of the effectiveness of > >> > >> > >>>the medicine, a shortened drug effect experienced > >>> > >>> > >>after 3 years of > >> > >> > >>>medication. Have you got the similar problem? > >>> > >>>Chris Lui > >>> > >>>----- Original Message ----- > >>>From: "Nancy S. deGrazia" > <[log in to unmask]> > >>>To: <[log in to unmask]> > >>>Sent: Tuesday, September 16, 2003 6:57 PM > >>>Subject: Re: COMTAN > >>> > >>> > >>> > >>> > >>> > >>> > >>>>Chris Lui:- iis the "end of dose" phenomenon you > >>>> > >>>> > >>referred to (A) a > >> > >> > >>>>premature ending of the effectiveness of the > >>>> > >>>> > >>medecine or (b) dyskinesia > >> > >> > >>>>which manifests itself at the end of a dose? > >>>> > >>>>Your response will clarify my situation for > which > >>>> > >>>> > >>I would be very > >> > >> > >>>> > >>>> > >>>grateful. > >>> > >>> > >>> > >>> > >>>>Nancy S deGrazia > >>>> > >>>> > >>>> > >>>>Chris Lui wrote: > >>>> > >>>> > >>>> > >>>> > >>>> > >>>>>Hi ALL, > >>>>> > >>>>>Today my neuro starts putting me on COMTAN to > >>>>> > >>>>> > >>addrerss the end of dose > >> > >> > >>>>> > >>>>> > >>>phenomenon. Any one has got any advice or > comment > >>> > >>> > >>about the use of this > >> > >> > >>>drug? Be it favourable or adverse, your > >>> > >>> > >>experience would certainly help! > >> > >> > >>>Thanks! > >>> > >>> > >>> > >>> > >>>>>Chris Lui > >>>>> > >>>>> > >>>>> > >>>>---------------------------------------------------------------------- > >>>> > >>>> > >>>>>To sign-off Parkinsn send a message to: > >>>>> > >>>>> > >>>>> > >>>>> > >>>mailto:[log in to unmask] > >>> > >>> > >>> > >>> > >>>>>In the body of the message put: signoff > parkinsn > >>>>> > >>>>> > >>>>> > >>>>> > >>>>> > >>>>> > >>>>> > >>>---------------------------------------------------------------------- > >>> > >>> > >>>>To sign-off Parkinsn send a message to: > >>>> > >>>> > >>>> > >>>> > >>>mailto:[log in to unmask] > >>> > >>> > >>> > >>> > >>>>In the body of the message put: signoff parkinsn > >>>> > >>>> > >>>> > >>>> > >>>> > >>---------------------------------------------------------------------- > >> > >> > >>>To sign-off Parkinsn send a message to: > >>> > >>> > >>mailto:[log in to unmask] > >> > >> > >>>In the body of the message put: signoff parkinsn > >>> > >>> > >>> > === message truncated === ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn