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I have taken COMTAN for only two days, and already felt that I enjoyed more
ON time and less OFF time at the end of dose.  I think it is a good drug for
me.  However, sometimes I felt a bit too tense and jerky with the
medication.  Does it mean that I am on the verge of having dyskynesia (I
used to not having dyskynesia) and should reduce Sinemet?  Could anyone
advice me with similar experiences?

Chris Lui

----- Original Message -----
From: "David Moreland" <[log in to unmask]>
To: <[log in to unmask]>
Sent: Thursday, September 18, 2003 1:25 PM
Subject: Re: COMTAN


> the pallidotomy marginally helped a lot of things. It
> not only got rid of the hellish dyskinesia.  Since my
>                      PVP I dfont have Migrains any
> more I bagan sleeping all night,  I was able to drive
> again,my PD medications started to work again they
> hadn't been working
>
> David Moreland
>
>
>
> --- "Nancy S. deGrazia" <[log in to unmask]>
> wrote:
> > David - that's good to hear.  Were your PD symptoms
> > across the board
> > (tremor, gait problems,  freezing, etc)? And which
> > ones did the
> > pallidotomy help?
> >
> > Nancy deG
> >
> > David Moreland wrote:
> >
> > >--- "Nancy S. deGrazia" <[log in to unmask]>
> > >wrote:
> > >
> > >
> > >>Thank you, Chris :
> > >>No. my "end of dose " phenomenom is the onset of
> > >>dyskinesia. I seem to
> > >>have both "peak dose" and "end of dose"
> > dyskinesia.
> > >>I have been taking
> > >>sinemet for almost 10 years and over that period
> > >>have added eldepryl,
> > >>permax, mirapex and amantadine. I guess the reason
> > I
> > >>am taking so many
> > >>different things is that I am hypersensitive to
> > >>levadopa. I take 1/4 of
> > >>a 25/100 every 90 minutes and if I take more the
> > >>dyskinesia is just awful..
> > >>
> > >>Anyone else with this kind of problem?
> > >>I used to have diskinesias  that on a 1  to  10
> > >>
> > >>
> > >scale mine were up to 13 or 14 . Then i had a
> > >pallidototomy.   For the most part I have been free
> > of
> > >dyskinesia  since then (1995}
> > >David Moreland
> > >
> > >
> > >>Nancy deG
> > >>
> > >>Chris Lui wrote:
> > >>
> > >>
> > >>
> > >>>Hi Nancy:
> > >>>
> > >>>My end of dose phenomenon refers to premature
> > >>>
> > >>>
> > >>ending of the effectiveness of
> > >>
> > >>
> > >>>the medicine, a shortened drug effect experienced
> > >>>
> > >>>
> > >>after 3 years of
> > >>
> > >>
> > >>>medication.  Have you got the similar problem?
> > >>>
> > >>>Chris Lui
> > >>>
> > >>>----- Original Message -----
> > >>>From: "Nancy S. deGrazia"
> > <[log in to unmask]>
> > >>>To: <[log in to unmask]>
> > >>>Sent: Tuesday, September 16, 2003 6:57 PM
> > >>>Subject: Re: COMTAN
> > >>>
> > >>>
> > >>>
> > >>>
> > >>>
> > >>>
> > >>>>Chris Lui:- iis the "end of dose" phenomenon you
> > >>>>
> > >>>>
> > >>referred to (A) a
> > >>
> > >>
> > >>>>premature ending of the effectiveness of the
> > >>>>
> > >>>>
> > >>medecine or (b) dyskinesia
> > >>
> > >>
> > >>>>which manifests itself at the end of a dose?
> > >>>>
> > >>>>Your response will clarify my situation for
> > which
> > >>>>
> > >>>>
> > >>I would be very
> > >>
> > >>
> > >>>>
> > >>>>
> > >>>grateful.
> > >>>
> > >>>
> > >>>
> > >>>
> > >>>>Nancy S deGrazia
> > >>>>
> > >>>>
> > >>>>
> > >>>>Chris Lui wrote:
> > >>>>
> > >>>>
> > >>>>
> > >>>>
> > >>>>
> > >>>>>Hi ALL,
> > >>>>>
> > >>>>>Today my neuro starts putting me on COMTAN to
> > >>>>>
> > >>>>>
> > >>addrerss the end of dose
> > >>
> > >>
> > >>>>>
> > >>>>>
> > >>>phenomenon.  Any one has got any advice or
> > comment
> > >>>
> > >>>
> > >>about the use of this
> > >>
> > >>
> > >>>drug?  Be it favourable or adverse,  your
> > >>>
> > >>>
> > >>experience would certainly help!
> > >>
> > >>
> > >>>Thanks!
> > >>>
> > >>>
> > >>>
> > >>>
> > >>>>>Chris Lui
> > >>>>>
> > >>>>>
> > >>>>>
> >
> >>>>----------------------------------------------------------------------
> > >>>>
> > >>>>
> > >>>>>To sign-off Parkinsn send a message to:
> > >>>>>
> > >>>>>
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> > >>>>>
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> > >>>
> > >>>
> > >>>
> > >>>
> > >>>>>In the body of the message put: signoff
> > parkinsn
> > >>>>>
> > >>>>>
> > >>>>>
> > >>>>>
> > >>>>>
> > >>>>>
> > >>>>>
> >
> >>>----------------------------------------------------------------------
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> >>----------------------------------------------------------------------
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> > >>>
> >
> === message truncated ===
>
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