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Hi Barry: Thanks for the experience. What do you mean exactly by "space out the sinemet"? Do you mean to increase the time interval between each dose of Sinemet, or to decrease the amount of Sinemet in each dose? Chris ----- Original Message ----- From: "Barry Black" <[log in to unmask]> To: <[log in to unmask]> Sent: Friday, September 19, 2003 3:11 AM Subject: Re: COMTAN > I get dyskinesia at end of day when I take Comtan. You may need to space out > the Sinemet or take a 1/2 comtan > ----- Original Message ----- > From: "Chris Lui" <[log in to unmask]> > To: <[log in to unmask]> > Sent: Thursday, September 18, 2003 10:21 PM > Subject: Re: COMTAN > > > > I have taken COMTAN for only two days, and already felt that I enjoyed > more > > ON time and less OFF time at the end of dose. I think it is a good drug > for > > me. However, sometimes I felt a bit too tense and jerky with the > > medication. Does it mean that I am on the verge of having dyskynesia (I > > used to not having dyskynesia) and should reduce Sinemet? Could anyone > > advice me with similar experiences? > > > > Chris Lui > > > > ----- Original Message ----- > > From: "David Moreland" <[log in to unmask]> > > To: <[log in to unmask]> > > Sent: Thursday, September 18, 2003 1:25 PM > > Subject: Re: COMTAN > > > > > > > the pallidotomy marginally helped a lot of things. It > > > not only got rid of the hellish dyskinesia. Since my > > > PVP I dfont have Migrains any > > > more I bagan sleeping all night, I was able to drive > > > again,my PD medications started to work again they > > > hadn't been working > > > > > > David Moreland > > > > > > > > > > > > --- "Nancy S. deGrazia" <[log in to unmask]> > > > wrote: > > > > David - that's good to hear. Were your PD symptoms > > > > across the board > > > > (tremor, gait problems, freezing, etc)? And which > > > > ones did the > > > > pallidotomy help? > > > > > > > > Nancy deG > > > > > > > > David Moreland wrote: > > > > > > > > >--- "Nancy S. deGrazia" <[log in to unmask]> > > > > >wrote: > > > > > > > > > > > > > > >>Thank you, Chris : > > > > >>No. my "end of dose " phenomenom is the onset of > > > > >>dyskinesia. I seem to > > > > >>have both "peak dose" and "end of dose" > > > > dyskinesia. > > > > >>I have been taking > > > > >>sinemet for almost 10 years and over that period > > > > >>have added eldepryl, > > > > >>permax, mirapex and amantadine. I guess the reason > > > > I > > > > >>am taking so many > > > > >>different things is that I am hypersensitive to > > > > >>levadopa. I take 1/4 of > > > > >>a 25/100 every 90 minutes and if I take more the > > > > >>dyskinesia is just awful.. > > > > >> > > > > >>Anyone else with this kind of problem? > > > > >>I used to have diskinesias that on a 1 to 10 > > > > >> > > > > >> > > > > >scale mine were up to 13 or 14 . Then i had a > > > > >pallidototomy. For the most part I have been free > > > > of > > > > >dyskinesia since then (1995} > > > > >David Moreland > > > > > > > > > > > > > > >>Nancy deG > > > > >> > > > > >>Chris Lui wrote: > > > > >> > > > > >> > > > > >> > > > > >>>Hi Nancy: > > > > >>> > > > > >>>My end of dose phenomenon refers to premature > > > > >>> > > > > >>> > > > > >>ending of the effectiveness of > > > > >> > > > > >> > > > > >>>the medicine, a shortened drug effect experienced > > > > >>> > > > > >>> > > > > >>after 3 years of > > > > >> > > > > >> > > > > >>>medication. Have you got the similar problem? > > > > >>> > > > > >>>Chris Lui > > > > >>> > > > > >>>----- Original Message ----- > > > > >>>From: "Nancy S. deGrazia" > > > > <[log in to unmask]> > > > > >>>To: <[log in to unmask]> > > > > >>>Sent: Tuesday, September 16, 2003 6:57 PM > > > > >>>Subject: Re: COMTAN > > > > >>> > > > > >>> > > > > >>> > > > > >>> > > > > >>> > > > > >>> > > > > >>>>Chris Lui:- iis the "end of dose" phenomenon you > > > > >>>> > > > > >>>> > > > > >>referred to (A) a > > > > >> > > > > >> > > > > >>>>premature ending of the effectiveness of the > > > > >>>> > > > > >>>> > > > > >>medecine or (b) dyskinesia > > > > >> > > > > >> > > > > >>>>which manifests itself at the end of a dose? > > > > >>>> > > > > >>>>Your response will clarify my situation for > > > > which > > > > >>>> > > > > >>>> > > > > >>I would be very > > > > >> > > > > >> > > > > >>>> > > > > >>>> > > > > >>>grateful. > > > > >>> > > > > >>> > > > > >>> > > > > >>> > > > > >>>>Nancy S deGrazia > > > > >>>> > > > > >>>> > > > > >>>> > > > > >>>>Chris Lui wrote: > > > > >>>> > > > > >>>> > > > > >>>> > > > > >>>> > > > > >>>> > > > > >>>>>Hi ALL, > > > > >>>>> > > > > >>>>>Today my neuro starts putting me on COMTAN to > > > > >>>>> > > > > >>>>> > > > > >>addrerss the end of dose > > > > >> > > > > >> > > > > >>>>> > > > > >>>>> > > > > >>>phenomenon. Any one has got any advice or > > > > comment > > > > >>> > > > > >>> > > > > >>about the use of this > > > > >> > > > > >> > > > > >>>drug? Be it favourable or adverse, your > > > > >>> > > > > >>> > > > > >>experience would certainly help! > > > > >> > > > > >> > > > > >>>Thanks! > > > > >>> > > > > >>> > > > > >>> > > > > >>> > > > > >>>>>Chris Lui > > > > >>>>> > > > > >>>>> > > > > >>>>> > > > > > > > > >>>>---------------------------------------------------------------------- > > > > >>>> > > > > >>>> > > > > >>>>>To sign-off Parkinsn send a message to: > > > > >>>>> > > > > >>>>> > > > > >>>>> > > > > >>>>> > > > > >>>mailto:[log in to unmask] > > > > >>> > > > > >>> > > > > >>> > > > > >>> > > > > >>>>>In the body of the message put: signoff > > > > parkinsn > > > > >>>>> > > > > >>>>> > > > > >>>>> > > > > >>>>> > > > > >>>>> > > > > >>>>> > > > > >>>>> > > > > > > > > >>>---------------------------------------------------------------------- > > > > >>> > > > > >>> > > > > >>>>To sign-off Parkinsn send a message to: > > > > >>>> > > > > >>>> > > > > >>>> > > > > >>>> > > > > >>>mailto:[log in to unmask] > > > > >>> > > > > >>> > > > > >>> > > > > >>> > > > > >>>>In the body of the message put: signoff parkinsn > > > > >>>> > > > > >>>> > > > > >>>> > > > > >>>> > > > > >>>> > > > > > > > >>---------------------------------------------------------------------- > > > > >> > > > > >> > > > > >>>To sign-off Parkinsn send a message to: > > > > >>> > > > > >>> > > > > >>mailto:[log in to unmask] > > > > >> > > > > >> > > > > >>>In the body of the message put: signoff parkinsn > > > > >>> > > > > >>> > > > > >>> > > > > > > > === message truncated === > > > > > > ---------------------------------------------------------------------- > > > To sign-off Parkinsn send a message to: > > mailto:[log in to unmask] > > > In the body of the message put: signoff parkinsn > > > > > > > ---------------------------------------------------------------------- > > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > > In the body of the message put: signoff parkinsn > > > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn