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Hi Chris, what I mean is increase the interval also try taking 1/2 of a Sinemet I have found over the years, with my degeneration, that I had to adjust my dose + or -- in mg as well as increase or decrease the interval. My doctor does not mind if I make small adjustments as every patient is different You will find that protein ( milk cheese,,meats etc)is the biggest preventer of the Sinemet getting into the brain as the protein can block out themeds for 1-3 hrs. I try to take my meds 1/2 before eating as in giving them a head start Regards ----- Original Message ----- From: "Chris Lui" <[log in to unmask]> To: <[log in to unmask]> Sent: Friday, September 19, 2003 8:50 AM Subject: Re: COMTAN > Hi Barry: > > Thanks for the experience. What do you mean exactly by "space out the > sinemet"? Do you mean to increase the time interval between each dose of > Sinemet, or to decrease the amount of Sinemet in each dose? > > Chris > ----- Original Message ----- > From: "Barry Black" <[log in to unmask]> > To: <[log in to unmask]> > Sent: Friday, September 19, 2003 3:11 AM > Subject: Re: COMTAN > > > > I get dyskinesia at end of day when I take Comtan. You may need to space > out > > the Sinemet or take a 1/2 comtan > > ----- Original Message ----- > > From: "Chris Lui" <[log in to unmask]> > > To: <[log in to unmask]> > > Sent: Thursday, September 18, 2003 10:21 PM > > Subject: Re: COMTAN > > > > > > > I have taken COMTAN for only two days, and already felt that I enjoyed > > more > > > ON time and less OFF time at the end of dose. I think it is a good drug > > for > > > me. However, sometimes I felt a bit too tense and jerky with the > > > medication. Does it mean that I am on the verge of having dyskynesia (I > > > used to not having dyskynesia) and should reduce Sinemet? Could anyone > > > advice me with similar experiences? > > > > > > Chris Lui > > > > > > ----- Original Message ----- > > > From: "David Moreland" <[log in to unmask]> > > > To: <[log in to unmask]> > > > Sent: Thursday, September 18, 2003 1:25 PM > > > Subject: Re: COMTAN > > > > > > > > > > the pallidotomy marginally helped a lot of things. It > > > > not only got rid of the hellish dyskinesia. Since my > > > > PVP I dfont have Migrains any > > > > more I bagan sleeping all night, I was able to drive > > > > again,my PD medications started to work again they > > > > hadn't been working > > > > > > > > David Moreland > > > > > > > > > > > > > > > > --- "Nancy S. deGrazia" <[log in to unmask]> > > > > wrote: > > > > > David - that's good to hear. Were your PD symptoms > > > > > across the board > > > > > (tremor, gait problems, freezing, etc)? And which > > > > > ones did the > > > > > pallidotomy help? > > > > > > > > > > Nancy deG > > > > > > > > > > David Moreland wrote: > > > > > > > > > > >--- "Nancy S. deGrazia" <[log in to unmask]> > > > > > >wrote: > > > > > > > > > > > > > > > > > >>Thank you, Chris : > > > > > >>No. my "end of dose " phenomenom is the onset of > > > > > >>dyskinesia. I seem to > > > > > >>have both "peak dose" and "end of dose" > > > > > dyskinesia. > > > > > >>I have been taking > > > > > >>sinemet for almost 10 years and over that period > > > > > >>have added eldepryl, > > > > > >>permax, mirapex and amantadine. I guess the reason > > > > > I > > > > > >>am taking so many > > > > > >>different things is that I am hypersensitive to > > > > > >>levadopa. I take 1/4 of > > > > > >>a 25/100 every 90 minutes and if I take more the > > > > > >>dyskinesia is just awful.. > > > > > >> > > > > > >>Anyone else with this kind of problem? > > > > > >>I used to have diskinesias that on a 1 to 10 > > > > > >> > > > > > >> > > > > > >scale mine were up to 13 or 14 . Then i had a > > > > > >pallidototomy. For the most part I have been free > > > > > of > > > > > >dyskinesia since then (1995} > > > > > >David Moreland > > > > > > > > > > > > > > > > > >>Nancy deG > > > > > >> > > > > > >>Chris Lui wrote: > > > > > >> > > > > > >> > > > > > >> > > > > > >>>Hi Nancy: > > > > > >>> > > > > > >>>My end of dose phenomenon refers to premature > > > > > >>> > > > > > >>> > > > > > >>ending of the effectiveness of > > > > > >> > > > > > >> > > > > > >>>the medicine, a shortened drug effect experienced > > > > > >>> > > > > > >>> > > > > > >>after 3 years of > > > > > >> > > > > > >> > > > > > >>>medication. Have you got the similar problem? > > > > > >>> > > > > > >>>Chris Lui > > > > > >>> > > > > > >>>----- Original Message ----- > > > > > >>>From: "Nancy S. deGrazia" > > > > > <[log in to unmask]> > > > > > >>>To: <[log in to unmask]> > > > > > >>>Sent: Tuesday, September 16, 2003 6:57 PM > > > > > >>>Subject: Re: COMTAN > > > > > >>> > > > > > >>> > > > > > >>> > > > > > >>> > > > > > >>> > > > > > >>> > > > > > >>>>Chris Lui:- iis the "end of dose" phenomenon you > > > > > >>>> > > > > > >>>> > > > > > >>referred to (A) a > > > > > >> > > > > > >> > > > > > >>>>premature ending of the effectiveness of the > > > > > >>>> > > > > > >>>> > > > > > >>medecine or (b) dyskinesia > > > > > >> > > > > > >> > > > > > >>>>which manifests itself at the end of a dose? > > > > > >>>> > > > > > >>>>Your response will clarify my situation for > > > > > which > > > > > >>>> > > > > > >>>> > > > > > >>I would be very > > > > > >> > > > > > >> > > > > > >>>> > > > > > >>>> > > > > > >>>grateful. > > > > > >>> > > > > > >>> > > > > > >>> > > > > > >>> > > > > > >>>>Nancy S deGrazia > > > > > >>>> > > > > > >>>> > > > > > >>>> > > > > > >>>>Chris Lui wrote: > > > > > >>>> > > > > > >>>> > > > > > >>>> > > > > > >>>> > > > > > >>>> > > > > > >>>>>Hi ALL, > > > > > >>>>> > > > > > >>>>>Today my neuro starts putting me on COMTAN to > > > > > >>>>> > > > > > >>>>> > > > > > >>addrerss the end of dose > > > > > >> > > > > > >> > > > > > >>>>> > > > > > >>>>> > > > > > >>>phenomenon. Any one has got any advice or > > > > > comment > > > > > >>> > > > > > >>> > > > > > >>about the use of this > > > > > >> > > > > > >> > > > > > >>>drug? Be it favourable or adverse, your > > > > > >>> > > > > > >>> > > > > > >>experience would certainly help! > > > > > >> > > > > > >> > > > > > >>>Thanks! > > > > > >>> > > > > > >>> > > > > > >>> > > > > > >>> > > > > > >>>>>Chris Lui > > > > > >>>>> > > > > > >>>>> > > > > > >>>>> > > > > > > > > > > > >>>>---------------------------------------------------------------------- > > > > > >>>> > > > > > >>>> > > > > > >>>>>To sign-off Parkinsn send a message to: > > > > > >>>>> > > > > > >>>>> > > > > > >>>>> > > > > > >>>>> > > > > > >>>mailto:[log in to unmask] > > > > > >>> > > > > > >>> > > > > > >>> > > > > > >>> > > > > > >>>>>In the body of the message put: signoff > > > > > parkinsn > > > > > >>>>> > > > > > >>>>> > > > > > >>>>> > > > > > >>>>> > > > > > >>>>> > > > > > >>>>> > > > > > >>>>> > > > > > > > > > > > >>>---------------------------------------------------------------------- > > > > > >>> > > > > > >>> > > > > > >>>>To sign-off Parkinsn send a message to: > > > > > >>>> > > > > > >>>> > > > > > >>>> > > > > > >>>> > > > > > >>>mailto:[log in to unmask] > > > > > >>> > > > > > >>> > > > > > >>> > > > > > >>> > > > > > >>>>In the body of the message put: signoff parkinsn > > > > > >>>> > > > > > >>>> > > > > > >>>> > > > > > >>>> > > > > > >>>> > > > > > > > > > > >>---------------------------------------------------------------------- > > > > > >> > > > > > >> > > > > > >>>To sign-off Parkinsn send a message to: > > > > > >>> > > > > > >>> > > > > > >>mailto:[log in to unmask] > > > > > >> > > > > > >> > > > > > >>>In the body of the message put: signoff parkinsn > > > > > >>> > > > > > >>> > > > > > >>> > > > > > > > > > === message truncated === > > > > > > > > ---------------------------------------------------------------------- > > > > To sign-off Parkinsn send a message to: > > > mailto:[log in to unmask] > > > > In the body of the message put: signoff parkinsn > > > > > > > > > > ---------------------------------------------------------------------- > > > To sign-off Parkinsn send a message to: > > mailto:[log in to unmask] > > > In the body of the message put: signoff parkinsn > > > > > > > ---------------------------------------------------------------------- > > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > > In the body of the message put: signoff parkinsn > > > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn