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Thank you, Chris : No. my "end of dose " phenomenom is the onset of dyskinesia. I seem to have both "peak dose" and "end of dose" dyskinesia. I have been taking sinemet for almost 10 years and over that period have added eldepryl, permax, mirapex and amantadine. I guess the reason I am taking so many different things is that I am hypersensitive to levadopa. I take 1/4 of a 25/100 every 90 minutes and if I take more the dyskinesia is just awful.. Anyone else with this kind of problem? Nancy deG Chris Lui wrote: >Hi Nancy: > >My end of dose phenomenon refers to premature ending of the effectiveness of >the medicine, a shortened drug effect experienced after 3 years of >medication. Have you got the similar problem? > >Chris Lui > >----- Original Message ----- >From: "Nancy S. deGrazia" <[log in to unmask]> >To: <[log in to unmask]> >Sent: Tuesday, September 16, 2003 6:57 PM >Subject: Re: COMTAN > > > > >>Chris Lui:- iis the "end of dose" phenomenon you referred to (A) a >>premature ending of the effectiveness of the medecine or (b) dyskinesia >>which manifests itself at the end of a dose? >> >>Your response will clarify my situation for which I would be very >> >> >grateful. > > >>Nancy S deGrazia >> >> >> >>Chris Lui wrote: >> >> >> >>>Hi ALL, >>> >>>Today my neuro starts putting me on COMTAN to addrerss the end of dose >>> >>> >phenomenon. Any one has got any advice or comment about the use of this >drug? Be it favourable or adverse, your experience would certainly help! >Thanks! > > >>>Chris Lui >>> >>>---------------------------------------------------------------------- >>>To sign-off Parkinsn send a message to: >>> >>> >mailto:[log in to unmask] > > >>>In the body of the message put: signoff parkinsn >>> >>> >>> >>> >>> >>---------------------------------------------------------------------- >>To sign-off Parkinsn send a message to: >> >> >mailto:[log in to unmask] > > >>In the body of the message put: signoff parkinsn >> >> >> > >---------------------------------------------------------------------- >To sign-off Parkinsn send a message to: mailto:[log in to unmask] >In the body of the message put: signoff parkinsn > > > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn