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Hi Nancy, I have the same dyskinesia (DK) problem. I take 6 sinemet 100+ others for 20 yrs and I had DBS in 1997. Meds Start time is 7 and I am "on" by 8 am. Usually I get mild DK after 8 but my real DK kicks in from 3-7 pm. I have a roller coaster ride every day with stiffness/freezing followed by DK. As you know DK is side effect of too much drugs and not a PD symptom Since PD is a resting tremor, I do the following 1-drink lots of milk (protein) as it reduces the levodopa to the brain 2- lie on my back on the floor with the bottom of my right foot against my left knee. I then tell myself to relax and after 1-2 minutes my DK has stopped. My neuro cant explain why it works.I think that it is because my resting tremor is not resting but is now actived MY neuro took me off COMTAN because it causes DK from 3-7 pm Instead I use CABASER/cabergoline Regards ---- Original Message ----- From: "Nancy S. deGrazia" <[log in to unmask]> To: <[log in to unmask]> Sent: Wednesday, September 17, 2003 1:13 PM Subject: Re: COMTAN > Thank you, Chris : > No. my "end of dose " phenomenom is the onset of dyskinesia. I seem to > have both "peak dose" and "end of dose" dyskinesia. I have been taking > sinemet for almost 10 years and over that period have added eldepryl, > permax, mirapex and amantadine. I guess the reason I am taking so many > different things is that I am hypersensitive to levadopa. I take 1/4 of > a 25/100 every 90 minutes and if I take more the dyskinesia is just awful.. > > Anyone else with this kind of problem? > > Nancy deG > > Chris Lui wrote: > > >Hi Nancy: > > > >My end of dose phenomenon refers to premature ending of the effectiveness of > >the medicine, a shortened drug effect experienced after 3 years of > >medication. Have you got the similar problem? > > > >Chris Lui > > > >----- Original Message ----- > >From: "Nancy S. deGrazia" <[log in to unmask]> > >To: <[log in to unmask]> > >Sent: Tuesday, September 16, 2003 6:57 PM > >Subject: Re: COMTAN > > > > > > > > > >>Chris Lui:- iis the "end of dose" phenomenon you referred to (A) a > >>premature ending of the effectiveness of the medecine or (b) dyskinesia > >>which manifests itself at the end of a dose? > >> > >>Your response will clarify my situation for which I would be very > >> > >> > >grateful. > > > > > >>Nancy S deGrazia > >> > >> > >> > >>Chris Lui wrote: > >> > >> > >> > >>>Hi ALL, > >>> > >>>Today my neuro starts putting me on COMTAN to addrerss the end of dose > >>> > >>> > >phenomenon. Any one has got any advice or comment about the use of this > >drug? Be it favourable or adverse, your experience would certainly help! > >Thanks! > > > > > >>>Chris Lui > >>> > >>>---------------------------------------------------------------------- > >>>To sign-off Parkinsn send a message to: > >>> > >>> > >mailto:[log in to unmask] > > > > > >>>In the body of the message put: signoff parkinsn > >>> > >>> > >>> > >>> > >>> > >>---------------------------------------------------------------------- > >>To sign-off Parkinsn send a message to: > >> > >> > >mailto:[log in to unmask] > > > > > >>In the body of the message put: signoff parkinsn > >> > >> > >> > > > >---------------------------------------------------------------------- > >To sign-off Parkinsn send a message to: mailto:[log in to unmask] > >In the body of the message put: signoff parkinsn > > > > > > > > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn