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David - that's good to hear. Were your PD symptoms across the board (tremor, gait problems, freezing, etc)? And which ones did the pallidotomy help? Nancy deG David Moreland wrote: >--- "Nancy S. deGrazia" <[log in to unmask]> >wrote: > > >>Thank you, Chris : >>No. my "end of dose " phenomenom is the onset of >>dyskinesia. I seem to >>have both "peak dose" and "end of dose" dyskinesia. >>I have been taking >>sinemet for almost 10 years and over that period >>have added eldepryl, >>permax, mirapex and amantadine. I guess the reason I >>am taking so many >>different things is that I am hypersensitive to >>levadopa. I take 1/4 of >>a 25/100 every 90 minutes and if I take more the >>dyskinesia is just awful.. >> >>Anyone else with this kind of problem? >>I used to have diskinesias that on a 1 to 10 >> >> >scale mine were up to 13 or 14 . Then i had a >pallidototomy. For the most part I have been free of >dyskinesia since then (1995} >David Moreland > > >>Nancy deG >> >>Chris Lui wrote: >> >> >> >>>Hi Nancy: >>> >>>My end of dose phenomenon refers to premature >>> >>> >>ending of the effectiveness of >> >> >>>the medicine, a shortened drug effect experienced >>> >>> >>after 3 years of >> >> >>>medication. Have you got the similar problem? >>> >>>Chris Lui >>> >>>----- Original Message ----- >>>From: "Nancy S. deGrazia" <[log in to unmask]> >>>To: <[log in to unmask]> >>>Sent: Tuesday, September 16, 2003 6:57 PM >>>Subject: Re: COMTAN >>> >>> >>> >>> >>> >>> >>>>Chris Lui:- iis the "end of dose" phenomenon you >>>> >>>> >>referred to (A) a >> >> >>>>premature ending of the effectiveness of the >>>> >>>> >>medecine or (b) dyskinesia >> >> >>>>which manifests itself at the end of a dose? >>>> >>>>Your response will clarify my situation for which >>>> >>>> >>I would be very >> >> >>>> >>>> >>>grateful. >>> >>> >>> >>> >>>>Nancy S deGrazia >>>> >>>> >>>> >>>>Chris Lui wrote: >>>> >>>> >>>> >>>> >>>> >>>>>Hi ALL, >>>>> >>>>>Today my neuro starts putting me on COMTAN to >>>>> >>>>> >>addrerss the end of dose >> >> >>>>> >>>>> >>>phenomenon. Any one has got any advice or comment >>> >>> >>about the use of this >> >> >>>drug? Be it favourable or adverse, your >>> >>> >>experience would certainly help! >> >> >>>Thanks! >>> >>> >>> >>> >>>>>Chris Lui >>>>> >>>>> >>>>> >>>>---------------------------------------------------------------------- >>>> >>>> >>>>>To sign-off Parkinsn send a message to: >>>>> >>>>> >>>>> >>>>> >>>mailto:[log in to unmask] >>> >>> >>> >>> >>>>>In the body of the message put: signoff parkinsn >>>>> >>>>> >>>>> >>>>> >>>>> >>>>> >>>>> >>>---------------------------------------------------------------------- >>> >>> >>>>To sign-off Parkinsn send a message to: >>>> >>>> >>>> >>>> >>>mailto:[log in to unmask] >>> >>> >>> >>> >>>>In the body of the message put: signoff parkinsn >>>> >>>> >>>> >>>> >>>> >>---------------------------------------------------------------------- >> >> >>>To sign-off Parkinsn send a message to: >>> >>> >>mailto:[log in to unmask] >> >> >>>In the body of the message put: signoff parkinsn >>> >>> >>> >>> >>> >> >> >> >---------------------------------------------------------------------- > > >>To sign-off Parkinsn send a message to: >>mailto:[log in to unmask] >>In the body of the message put: signoff parkinsn >> >> > >---------------------------------------------------------------------- >To sign-off Parkinsn send a message to: mailto:[log in to unmask] >In the body of the message put: signoff parkinsn > > > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn