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Hi this has been perplexing me for the longest of time. All things being equal, a PWP gets up in the morning, he/she is slow, a bit disoriented, confused, but otherwise, can function with a certain degree of confidence until the meds are taken, in order to be better. So far so good. If the PWP takes a Sinemet Regular (yellow pill), the PWP now gets into what I call the "sinemet domain". If for any reason, the PWP "forgets" to take a follow-up dose or allows the sinemet to become depleted, the PWP not only goes back to his wake-up condition, but gets carried further, to dead-zone state, all life taken out, inert, unable to speak, move, entropy set in. Question: what or why does this happen? and can it be corrected/avoided? Sincerely, ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn Mario