Firstly I'd like to say a big thank you to everyone who contributes to the list and for the huge help you've been to me and my husband. I've been a member for some years but have never posted before. My husband is 54 and was diagnosed 6 years ago, he'd had symptoms for well over 3 years previous to diagnosis. His first medications was Requip but apart from bad side-effects it didn't seem to help his rigidity or shuffling walk. I think at that time he underwent a test and was given, under supervision, a "large" dose of L-dopa to check that he was able respond to it. Medication was changed and over the years he's taken a "cocktail" of medication with modifications from time to time. He has volunteered to be member of a trial to take place, here in Germany, where retina cells are implanted in the brain. However, when he went for the first meeting the doctor said she thought that he was atypical and not responding to the medication as a typical pwp would. One basis seems to be the fact that he doesn't get a big "boost" first thing in the morning. His medication is as follows: Cabaseril 8mg pro day (4mg early a.m.) comtess 1200mg (6x200) nacom 5x100mg and 200mg retard before bed and tregor 2x200mg. His meeting was on Wednesday and today his neuro's secretary phoned asking him to go for tests this coming Monday following a call from the trail doc. to his neuro. We have great faith in his neuro who has said Tony is slightly under-medicated so that he can keep going longer. Tony is getting worse but still has a full-time university job although he gave up being head of department in June this year. He doesn't always remember to take his meds on time and can be up to a couple of hours late. Has anyone else been told they are atypical or have any comments to make on the dosage my husband is taking? Thank you very, very much for any help you can give and sorry this is such a long message. Judith ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn