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Medtronic Device Is Shown To Ease Parkinson's Symptoms
Published November 13, 2003

Medtronic Incorporated's implanted brain-stimulating device helps Parkinson's disease patients move and allows them to
control the condition for at least five years, according to a study published in today's (Nov. 13) New England Journal
of Medicine.

The Activa system isn't a cure and doesn't stop all symptoms of the disease from worsening, said pioneering researchers
in Grenoble, France, who adapted the heart-pacemaker technology for Parkinson's patients in 1993. Even so it offers
such advantages as allowing patients to reduce their levels of levodopa, a drug that can affect motor skills and cause
involuntary movements.

Patients who aren't helped by medicines or who suffer side effects may benefit the most from Activa, researchers said.
The device, about the size of a stopwatch, sends constant electric shocks deep into the brain to help rebalance and
control movement in patients with the degenerative disease.

"The unique contribution of stimulation therapy is the marked and sustained effect it has on the disabling motor
complications that are associated with levodopa therapy," said Anthony Lang of the University of Toronto in an article
that accompanied the report. "Its efficacy is no greater."

Medtronic, the world's biggest maker of pacemakers, provided a grant to one of the researchers. Other support for the
study came from the French ministry of health and other European government agencies and universities. Activa won U.S.
approval in 1997.

Shares of Fridley-based Medtronic rose 52 cents to $44.37 in New York Stock Exchange composite trading. The company
separately said Wednesday that its fiscal second-quarter profit rose 58 percent, helped by sales of heart devices.

SOURCE: Bloomberg News / Minneapolis Star Tribune, MN
http://www.startribune.com/stories/535/4209307.html

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