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Singing Birds May Lead To New Health Discovery

(Middletown-WTNH, Nov. 24, 2003 5:00 PM) _ What do birds and botox have to do with the human brain? There's a unique
study going on at the neuroscience and behavior department at Wesleyan University. It's basic research that could lead
to new treatment for Alzheimer's or Parkinson's disease.

Watch the story with News Channel 8's Jocelyn Maminta
http://video.wtnh.com/news/2003/nov/clips/11242003-botox.ram

Their sweet sound could be the high note researchers are looking for in trying to understand how a human brain
functions.

"Birds are really unique among warm blooded animals in that they continue to produce new brain cells in a really
widespread manner throughout life."

How that could lead to therapies for brain damage in humans has John Kirn overseeing a study with songbirds at Wesleyan
University. That's because the canary and the zebra finch are able to produce new brain cells specifically for singing.


"So it provides us with a very specific part of the brain to look at in terms of trying to relate brain functions to
behavior."

There is something else unique about this research? They're using botox to figure out how the birds are able to
manufacture new cells. The botox is injected temporarily paralyzing the birds' vocal chords so they can't control
making their own music.

"Then we can get an idea, how much, which components of this complex behavior are in fact regulating neuronal
replacements."

You can actually hear how the botox impacts the birds' song. It's certainly not as clear as the first time you heard
it. If researchers are able to determine how songbirds regenerate new brain cells to replace old ones they could find a
way to duplicate that process in the human brain. The study is being funded by the national institutes of health. The
results will be published next May.

SOURCE: WTNH, CT
http://www.wtnh.com/global/story.asp?s=1538594&ClientType=Printable

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