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Folks, Do you know any Parkies who have taken Zanaflex? Zanaflex, generic name Tizanidine Hydrochloride is a very effective antispasmodic that is used for muscle spasticity in Multiple Sclerosis. Muscles tend to go into a tight contraction and not relax. This is referred to as muscle spasticity . When contractions are strong and painful they are called cramps. There are many causes of muscle spasms and stiffness. In MS, the medications Zanaflex, Baclofen and Valium are used for this My Parkie sister says at night she roams the house, has trouble sleeping, can't turn over , her legs become stiff and she can't relax them She says her legs get so stiff they become sore. Yes, she could take more Sinemet but she prefers not to [Dx 1996 ... has 8 years now], so we were talking about looking at other possible solutions. She currently takes Sinemet 25/100 four times a day, Comtan 200 mg with the Sinemet [four times a day] and Mirapex 1 mg three times a day. Has anyone on the list heard of Parkies taking Zanaflex or Baclofen for this purpose and what was your experience? Zanaflex would be great because it's fast acting, legs relax and tends to make you very sleepy! Thanks, Gail Vass ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn