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Hi Gail, I take Zanaflex at night and it does make you sleepy. I take 4 mg, but it isn't enough to take away dystonia. I either have to fall asleep before dystonia hits or still take a little sinemet to get rid of it. I wake up in 4 or 5 hours, but do sleep soundly. Since waking up means more dystonia and being totally off, I take 2 more mg of zanaflex with PD med, and always go back to sleep after some prowling, stretching, and meds. It's not as good as 7 straight hours, but it's much more rest than I used to get. At this dosage, I don't feel sluggish the next day. Without it, I wouldn't sleep nearly as well or as long, so I like it. Paula Wittekind ----- Original Message ----- From: "Gail Vass" <[log in to unmask]> To: <[log in to unmask]> Sent: Thursday, December 18, 2003 1:07 PM Subject: Do you know any Parkies who have taken Zanaflex? > Folks, > > Do you know any Parkies who have taken Zanaflex? > > Zanaflex, generic name Tizanidine Hydrochloride is a very effective > antispasmodic that is used for muscle spasticity in Multiple Sclerosis. > Muscles tend to go into a tight contraction and not relax. This is referred > to as muscle spasticity . > > When contractions are strong and painful they are called cramps. > There are many causes of muscle spasms and stiffness. In MS, the > medications Zanaflex, Baclofen and Valium are used for this > > My Parkie sister says at night she roams the house, has trouble sleeping, > can't turn over , her legs become stiff and she can't relax them She says > her legs get so stiff they become sore. > > Yes, she could take more Sinemet but she prefers not to [Dx 1996 ... > has 8 years now], so we were talking about looking at other possible solutions. > > She currently takes Sinemet 25/100 four times a day, Comtan 200 mg with > the Sinemet [four times a day] and Mirapex 1 mg three times a day. > > Has anyone on the list heard of Parkies taking Zanaflex or Baclofen for this > purpose and what was your experience? Zanaflex would be great because > it's fast acting, legs relax and tends to make you very sleepy! > > Thanks, > Gail Vass > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn