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First off: I don't have Parkinson's, so take this with that grain of salt. But my sister does, and went through two awful periods that put her in the hospital for a week each time last year to get re-stabilized. Each time it boiled down to a self-application of an 'optional' application of Sinemet. Her script at that time included a small number of extra pills, in addtion to the regular doses spread out through the day. She could take these as she judged best, and somehow, between the rush of 'normalcy' that they brought and her progressing condition, she would both lose track of time and be overwhelmed by the desire to be unfrozen. Two rounds of medication stabilization have her back on a strict clock of dosages, and life is much better. Judging only from her experience, I can only say that in some cases the clock has to rule with absurd power or things just get worse. I keep hoping that there will be some sort of patch or long term shot that would let her get some distance from her meds bag and a watch, but so far the docs haven't sent her that way. One thing you can do: pay particular attention to the different cycles you're on for the different meds and see if you can find a pattern of effectiveness. My sister's had better luck with adjusting the time of day/night that she takes various meds, but it took time to figure that out. The docs love a filled out schedule along with notations about how you feel, what you'd eaten, exercise, etc. to compare to your meds schedule. I'm sure that's a drag to do, but it does help. Best wishes and good luck. John in Flint, MI ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn