Hello, My Father has had Parkinson's for 8 years now. Almost from the start he has been on Bromocriptine and Siminet. From time to time his Neuro has tried other medications (Requip, Comtan) with very negative results. In the end my Father is worse off after having had tried the new medication then he was before. Recently the side effects of the Bromocriptine & Siminet have worsened. In fact my Father seems to be better of in the morning before taking his first dosage. In the morning he has difficulty walking but can do so extremely slowly without ever falling, in addition his facial expressions, speech and upper body movement are much better in morning. As the day progresses and he takes more medication for a brief period he may experience some improvement walking but as the day goes on he experience more freezing and a great deal of involuntary movement to the point were he will fall down quite often and has a hard time doing just about everything. So basically without medication he has problems walking but can do everything else reasonably well and with medication he can walk slightly better for perhaps 1 hour a day but after that it's down hill from there, significantly. Does this sound like something that could be helped with a medication vacation? I am concerned that his neuro will simply suggest increasing his medication and I'm quite positive that will make things worse. I would appreciate any suggestions. Thank you. Roberto Correia ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn