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Larry, my husband was well into his disease when Mirapex appeared on the
scene.  Jamie has YOPD and had been on a regimen of Sinemet, Eldepryl and
Amantadine.  He was suffering not only from severe dystonia but from tremors
and depression well  Of course, he denied that he was depressed, but he
didn't interact with anyone outside of work.

When he began Mirapex his tremors and dystonia virtually disappeared.  He
also became animated and suddenly decided that he enjoyed a social life.
The changes in his condition were startling.

Mirapex carries its baggage, however.  Jamie is extremely sensitive to it
and hallucinates when he is even slightly over-dosed so we are constantly
fine-tuning the drug.  Right now he is on .88 mgm of Mirapex and is
maintaining well - only because his neuro has listened carefully and has
properly prescribed a .125 mgm for his night-time tab.

Jamie's disease is quite advanced now.  If he were to be newly diagnosed at
this point the movement disorder specialists in our area seem to agree that
Mirapex would be a first-line drug for him.

Incidentally, when Jamie goes to the hospital the pharmacy tries to change
his Mirapex to a more moderately priced Requip.  We always refuse to allow
that switch.  Apparently, although the drugs are very similar, Requip
doesn't do as good a job on depression as Mirapex does - and, at any rate,
we're not about to change his regimen when he is in the midst of a medical
crisis.
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God bless
Mary Ann (CG Jamie 64/24)



 Thank you for the mention of the Mirapex. COuld you tel
> me...whjen did he start the Mirapex... after he was first diagnosed?  Or
had he been on
> other medication for a while?
> My regimen has been unchanged(except for the dosages) since I was
diagnosed.
>

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