Larry, my husband was well into his disease when Mirapex appeared on the scene. Jamie has YOPD and had been on a regimen of Sinemet, Eldepryl and Amantadine. He was suffering not only from severe dystonia but from tremors and depression well Of course, he denied that he was depressed, but he didn't interact with anyone outside of work. When he began Mirapex his tremors and dystonia virtually disappeared. He also became animated and suddenly decided that he enjoyed a social life. The changes in his condition were startling. Mirapex carries its baggage, however. Jamie is extremely sensitive to it and hallucinates when he is even slightly over-dosed so we are constantly fine-tuning the drug. Right now he is on .88 mgm of Mirapex and is maintaining well - only because his neuro has listened carefully and has properly prescribed a .125 mgm for his night-time tab. Jamie's disease is quite advanced now. If he were to be newly diagnosed at this point the movement disorder specialists in our area seem to agree that Mirapex would be a first-line drug for him. Incidentally, when Jamie goes to the hospital the pharmacy tries to change his Mirapex to a more moderately priced Requip. We always refuse to allow that switch. Apparently, although the drugs are very similar, Requip doesn't do as good a job on depression as Mirapex does - and, at any rate, we're not about to change his regimen when he is in the midst of a medical crisis. --------- God bless Mary Ann (CG Jamie 64/24) Thank you for the mention of the Mirapex. COuld you tel > me...whjen did he start the Mirapex... after he was first diagnosed? Or had he been on > other medication for a while? > My regimen has been unchanged(except for the dosages) since I was diagnosed. > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn