Hi!
I have been touched by this statement of Frank dated 14th Feb 2004:
" I Need Information on Parkinson's! I Need Help with this disease! I Need
Guidance on what to do medically and emotionally not politically or
religiously! I Need to Understand this thing! I Need to hear others
experience! I need help! I Need Hope!"
This represents the sole purpose of this forum. Here I would like to
focus of Pain & PD.
This is my experience with Pain and PD.
Alost 15-20 years before I was diagnosed with PD, my problem was pain in
my right shoulder.
PD or Pain, whhich came first?
In my case, PD came first, even though I did not realize it. As a hind
sight, we all probably realize that we had symptoms of PD long before we
were diagnozed, only after being diagnozed.
I had my partially masked face in my 30s, shoulder pain in my 40s, and
frozen shoulder in my 50s. No one told me that these were symptoms of PD.
I was diagnozed with different things including gout, tendonites,
spondilytes etc. I was given all kinds of physiotherapy which were only of
temporary comfort. Sooner or later, as the disease progresed, the pain as
well as other symptoms such as dystonia, bradykinesia, postural instability,
drooling, and other things slowly crept on me. Fom my experience, I think
this is the sequence of events:
Slow death of dopaminergic neurons,
Inflammation causing pain at initial site of physical problems,
Inflammatoy cytokines (Eg. IL1beta) level goes up in the blood. I am
not sure if IL1beta can cross brain blood barrier. If it does, then this
could cause additional problem in the brain such as aggravating the
inflammation of glial cells accelarating the progression of PD.
I am going through a rough period of pain currently. Assuming thatmy
hip and shoulder pain could aggravate the PD symptoms, I have been taking
Ibuprofen, which caused increase in weight and blood pressure. Therefoe, I
shifted o celebrex. In my expereince, celebrex completely reducedmst f my
symptoms, including postural instability!
I think one has to take into account the role of inflammation, pain and the
inflammatory cytokines in the progression of PD.
**********
FYI, I am quoting somebody else's statement regarding Pain & PD below:
"Subject: Re: PD and Pain
From: "Anonymous" <[log in to unmask]>
Date: Thu, 12 Feb 2004 22:08:51 -0600
X-Message-Number: 5
This is interesting...Sounds like it is caused from PD...but could
be that
PD patients have pain in shoulder from PD and then get frozen
shoulder
because they are not moving arm because of PD pain...huh?
comment
fact is we don't know which comes first and your supposition is a
reasonable one"
************
The purpose of this email is to request you to post your experience with
PD and Pain. Such data may induce research on this aspect of PD.
Thanks for your cooperation.
More on Pain & PD later.
Brightline
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