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This is interesting information, (sorry "Brightline" not sure of your name), especially considering a direct correlation between inflammation and worsening of symptoms of PD. Does anyone else have any information that draws any correlation between inflammation, autoimmune disorders and PD? This of course may be a chicken and egg thing, which come first or are they even related at all. There are many aging problems not all related to PD but our bodies work as a system and there is always interaction. My wife was diagnosed in her late 40's and has similar complaints, though no frozen shoulders, looking back it was also possible to see where many of her complaints were misdiagnosed at first. She is now experiencing back pain, shoulder pain, neck pain and her posture has transformed to the point where she is becoming unstable when standing. She to uses Ibuprofen. I did not know is caused increases in blood pressure and weight. I will have to look into that drug. She also has Hashimoto's Thyroiditis and was suspected of having a very rare disorder Hashimoto's Encephalopathy (please forgive the spelling). Both of these (though there is much debate about the second) are autoimmune disorders. The first is where the Thyroid is attacked by the autoimmune system eventually causing it to underperform. The second is where the same immune system attacks the brain and causes many symptoms. Imagine a PWP with this problem... The treatment that worked was high doses of steroids and then a maintenance dose. A great side effect during the course of treatment was an almost total elimination of her asthma symptoms (reduction of inflammation in lungs). Since we have stopped the steroids it seems she is now experiencing more pain. I wonder if this could be inflammation you mentioned? I will have to speak to the neurologist about it. Of course we have to consider the same conditions without PD. When you don't exercise you become stiff and more susceptible to pain, you have pain and exercise less. You exercise less and you lose strength. You lose strength you lose muscle tone. It is a vicious cycle. The University of Pittsburgh had an ongoing study looking at exercise programs and PD. It did not take a rocket scientist to determine what the outcome was: more exercise, less pain, better strength, better posture and fewer PD symptoms. This was not a miracle but the effects were obvious. Have you been participating in some kind of exercise program? "Use it or lose it" is always wise advice and a good course to follow. It does take encouragement and a few life style changes. I am going to focus on that for my wife. Frank cg. Teri 52/47/40 15024 ----- Original Message ----- From: "Brightline" <[log in to unmask]> To: <[log in to unmask]> Sent: Sunday, February 15, 2004 6:52 AM Subject: Focus Needed... Pain & PD > Hi! > I have been touched by this statement of Frank dated 14th Feb 2004: > > " I Need Information on Parkinson's! I Need Help with this disease! I Need > Guidance on what to do medically and emotionally not politically or > religiously! I Need to Understand this thing! I Need to hear others > experience! I need help! I Need Hope!" > > This represents the sole purpose of this forum. Here I would like to > focus of Pain & PD. > This is my experience with Pain and PD. > > Alost 15-20 years before I was diagnosed with PD, my problem was pain in > my right shoulder. > PD or Pain, whhich came first? > In my case, PD came first, even though I did not realize it. As a hind > sight, we all probably realize that we had symptoms of PD long before we > were diagnozed, only after being diagnozed. > I had my partially masked face in my 30s, shoulder pain in my 40s, and > frozen shoulder in my 50s. No one told me that these were symptoms of PD. > I was diagnozed with different things including gout, tendonites, > spondilytes etc. I was given all kinds of physiotherapy which were only of > temporary comfort. Sooner or later, as the disease progresed, the pain as > well as other symptoms such as dystonia, bradykinesia, postural instability, > drooling, and other things slowly crept on me. Fom my experience, I think > this is the sequence of events: > Slow death of dopaminergic neurons, > Inflammation causing pain at initial site of physical problems, > Inflammatoy cytokines (Eg. IL1beta) level goes up in the blood. I am > not sure if IL1beta can cross brain blood barrier. If it does, then this > could cause additional problem in the brain such as aggravating the > inflammation of glial cells accelarating the progression of PD. > I am going through a rough period of pain currently. Assuming thatmy > hip and shoulder pain could aggravate the PD symptoms, I have been taking > Ibuprofen, which caused increase in weight and blood pressure. Therefoe, I > shifted o celebrex. In my expereince, celebrex completely reducedmst f my > symptoms, including postural instability! > I think one has to take into account the role of inflammation, pain and the > inflammatory cytokines in the progression of PD. > ********** > FYI, I am quoting somebody else's statement regarding Pain & PD below: > > "Subject: Re: PD and Pain > From: "Anonymous" <[log in to unmask]> > Date: Thu, 12 Feb 2004 22:08:51 -0600 > X-Message-Number: 5 > > This is interesting...Sounds like it is caused from PD...but could > be that > PD patients have pain in shoulder from PD and then get frozen > shoulder > because they are not moving arm because of PD pain...huh? > > comment > fact is we don't know which comes first and your supposition is a > reasonable one" > ************ > The purpose of this email is to request you to post your experience with > PD and Pain. Such data may induce research on this aspect of PD. > > Thanks for your cooperation. > > More on Pain & PD later. > > Brightline > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn