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Raj, I was interested in your comments about celebrex. How much celebrex are you taking? And how quickly does it work for you? Eileen ----- Original Message ----- From: "Brightline" <[log in to unmask]> To: <[log in to unmask]> Sent: Friday, February 27, 2004 10:02 PM Subject: Re: Focus Needed... Pain & PD > Hi Shirley: > We are just comparing notes. If there is a higher percentageof people > first diagnozed with hyothyroidism (or hyperthyroidism), this may indicate > that malfunction of thyroid and the accompanying chronic fatigueness could > be taken as a warning as to what might follow. So also is the chronic pain > phenomenon. So far nobody attributes these as probable early symptoms of > the oncoming manifestation of PD. > At least in my case, I am fairly confident that this is so. > I am just stating my personal expereince and am trying to rationalize > what might be going on in my body. For example, as soon as I take celebrex, > not only my pain disappears, so do all the other symptoms of PD including > tremer, bradykinesia, and even postural instability. > Celebrex is an antiinflammatory agent, and is a COX-2 (Cyclo-oxigenase > 2) inhibitor. It can pass through the blood brain barrier. For the > progression of PD, COX2 function is required. If you can inhibit it, could > we slow the progression of PD? > I personally think, we can. Celebrex is relatively safer than other > non-steroidal antiinflamation drugs (NSAIDs) to consume. I have started > taking it whenever I have pain, because I do not have time to wait for the > results of a doubleblind study, which nobody has even undertaken yet. For me > it is important to save my neurons from dying right now and I shall do > anything to stop them from doing so. Because, once we lose them, it is very > difficult to make fresh ones (More on this later). > I am just sharing my experience. I am not giving any advise nor I am > qualified to give one. When you see your doctor next time, you can ask > her/him about this, if you like. > Raj > ********** > ----- Original Message ----- > From: "Shirley Lund" <[log in to unmask]> > To: <[log in to unmask]> > Sent: Thursday, February 26, 2004 2:50 PM > Subject: Re: Focus Needed... Pain & PD > > > > i just read several entries that folks were diagnosed with hypothyroidism > > around the time they were diagnosed with pd. so was i...this must be > > common? shirley > > ----- Original Message ----- > > From: "Brightline" <[log in to unmask]> > > To: <[log in to unmask]> > > Sent: Wednesday, February 25, 2004 9:42 AM > > Subject: Focus Needed... Pain & PD > > > > > > > David: > > > Thanks for sharing your experience. > > > If we share our experiences like this, we probably should be able to > > get > > > a better handle on the various symptoms that might forewarn what is > coming > > > next to haunt us like PD or anything for that matter. > > > PD as far as I know is still diagnozed by the common symptoms such > as > > > tremor, micrographia (?) or small handwriting, > > > dystonia, bradykinesia, postural instability etc. These are probably > > the > > > symptoms that were used to recognize this disease originally by Dr. > > > Parkinson himself. > > > Unfortunately, by the time one begins to show the physical symptoms, > > we > > > have lost about 70-80% of the dopaminergic neurons! Once this has > > happenned > > > it is very difficult and time consuming to regain the dead neurons by > the > > > neuroregeneratve process that is constanly going on in our body. As the > > PD > > > progresses more and more neurons are dying not only because of PD but > also > > > because of aging. This makes it tough on our body to regain the lost > > > neurons. Therefore I think it is very important that we should be able > to > > > recognize the disease early and help regeneration of the endogenous > > neuronal > > > stem cells, which will help retardthe progression of the disease. > > > More on this later. > > > Raj > > > ************ > > > ----- Original Message ----- > > > From: "DAVID LEWIN" <[log in to unmask]> > > > To: <[log in to unmask]> > > > Sent: Tuesday, February 24, 2004 8:24 AM > > > Subject: Re: Focus Needed... Pain & PD > > > > > > > > > > To add to the list, I too was first diagnosed with hypothyroidism. > The > > > > synthyroid greatly reduced my fatigue for a while. But then I was > > > diagnosed > > > > with PD, and that shifted my focus. We need to know more obviously > > about > > > > the autoimmune response. David > > > > > > > > > > > > >From: Brightline <[log in to unmask]> > > > > >Reply-To: Parkinson's Information Exchange Network > > > > ><[log in to unmask]> > > > > >To: [log in to unmask] > > > > >Subject: Re: Focus Needed... Pain & PD > > > > >Date: Thu, 19 Feb 2004 11:34:28 -0400 > > > > > > > > > >My experience was slightly different. > > > > >I was diagnozed with hypothyroidism and started taking synthroid. > This > > > > >eliminated my fatigue for a while. But, my pain took over my > > attention. > > > > >After a few years I was diagnozed with PD. As a hindsight, I now > > strongly > > > > >believe that if I had controlled my pain early enough, I would have > > > slowed > > > > >the prgression of PD. > > > > >Raj > > > > >********* > > > > >----- Original Message ----- > > > > >From: "Wendy Siegel" <[log in to unmask]> > > > > >To: <[log in to unmask]> > > > > >Sent: Wednesday, February 18, 2004 2:19 PM > > > > >Subject: Re: Focus Needed... Pain & PD > > > > > > > > > > > > > > > > I see some commonalities between your wife's experience and my > > > > > > husband's, things that may or may not be coincidence. > > > > > > > > > > > > You wrote: > > > > > > > > > > > > "Does anyone else have any information that draws any correlation > > > > > > between > > > > > > inflammation, autoimmune disorders and PD? ... The first is > > > > > > where the Thyroid is attacked by the autoimmune system eventually > > > > > > causing it > > > > > > to underperform." > > > > > > > > > > > > My husband has recently developed a goiter. That was what > eventually > > > led > > > > > > me to diagnose his PD. After researching it and other symptoms on > > the > > > > > > web, I got the diagnoses down to hyperthyroidism or PD. The > thyroid > > > > > > doctor said all was normal, that's when I knew it was PD. He said > > they > > > > > > don't know the cause of the goiter. Rich still has it, some days > it > > is > > > > > > larger than other days. So far, we can't determine what affects > it. > > > > > > > > > > > > > > > > > > You wrote: > > > > > > "A great side effect during the course of treatment was an almost > > > > > > total elimination of her asthma symptoms (reduction of > inflammation > > in > > > > > > lungs). Since we have stopped the steroids it seems she is now > > > > > > experiencing > > > > > > more pain." > > > > > > > > > > > > Rich had asthma as a child, and has in the past used steroids. He > > > hasn't > > > > > > had problems with asthma in years though. > > > > > > > > > > > > Wendy > > > > > > > > > > > > > > ---------------------------------------------------------------------- > > > > > > To sign-off Parkinsn send a message to: > > > > >mailto:[log in to unmask] > > > > > > In the body of the message put: signoff parkinsn > > > > > > > > > > >---------------------------------------------------------------------- > > > > >To sign-off Parkinsn send a message to: > > > > >mailto:[log in to unmask] > > > > >In the body of the message put: signoff parkinsn > > > > > > > > _________________________________________________________________ > > > > Store more e-mails with MSN Hotmail Extra Storage - 4 plans to choose > > > from! > > > > http://click.atdmt.com/AVE/go/onm00200362ave/direct/01/ > > > > > > > > ---------------------------------------------------------------------- > > > > To sign-off Parkinsn send a message to: > > > mailto:[log in to unmask] > > > > In the body of the message put: signoff parkinsn > > > > > > ---------------------------------------------------------------------- > > > To sign-off Parkinsn send a message to: > > mailto:[log in to unmask] > > > In the body of the message put: signoff parkinsn > > > > > > > ---------------------------------------------------------------------- > > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > > In the body of the message put: signoff parkinsn > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn