Hi Bob:
Could you please post the references on this?
Thanks.
Raj
*******
----- Original Message -----
From: "Bob Martone" <[log in to unmask]>
To: <[log in to unmask]>
Sent: Wednesday, April 28, 2004 2:27 PM
Subject: Nitric Oxide and PD
> Hello List members,
>
> I have been silent for a long time but I couldn't resist doing a
> little follow up on the Nitric oxide discovery at John's Hopkins.
>
> After reading about the damage caused by too much nitric oxide in
> PWP's I did a little search and discovered that Interferon-beta-1-b
> (IFN-ß) decreases induced Nitric Oxide (NO) production by a human
> astrocytoma cell line.
>
> Is this interferon available to PWP's and can it be used clinically
> today? Wouldn't that be a revolutionary change in PD treatment.
>
> Regards
>
> Bob Martone
>
>
> ------------------------------------------
>
>
> Interferon-beta-1-b (IFN-ß) Decreases Induced Nitric Oxide (NO)
> Production By A Human Astrocytoma Cell Line
>
>
> Guthikonda P, Baker J, Mattson DH
> J NeuroImmunol 1998 Mar 1;82(2):133-9
> Univ of Pennsylvania, Student School of Dentistry, Philadelphia 19104,
> USA
>
>
>
> _____
>
>
>
>
> <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Display&d
> opt=pubmed_pubmed&from_uid=98246901> UI# 98246901
> Abstract
>
>
> Inducible Nitric Oxide Synthase (iNOS) is expressed by
> <http://www.albany.net/~tjc/gloss1-g.html#Astrocyte> Astrocytes in
> DeMyelinating regions of Multiple Sclerosis (
> <http://www.albany.net/~tjc/gloss1-m.html#MS> MS) Brain plaques,
> suggesting that NO contributes to MS pathology.
>
> Since the ImmunoSuppressive
> <http://www.albany.net/~tjc/gloss1-c.html#Cytokines> Cytokine IFN-ß
> ameliorates MS disease activity, it is of interest to assess the
> modulatory role of IFN-ß on NO production.
>
> We studied the effects of IFN-ß, as well as Dexamethasone, IL-10, and
> Transforming Growth Factor-ß (TGF-ß), on Cytokine-induced NO
> production by the human Astrocytoma cell line, A172.
>
> L-NMMA and Aminoguanidine, competitive inhibitors of iNOS suppressed
> <http://www.albany.net/~tjc/nitric-oxide_axons.html#1#1> NO production
> as measured by the NO byproduct, Nitrite, as did
> <http://www.albany.net/~tjc/gloss1-i.html#beta> Interferon-ß.
>
> Dexamethasone enhanced NO production, and IFN-ß decreased the amount
> of the enhancement. Neither
> <http://www.albany.net/~tjc/interleukin.html#IL-10> IL-10 nor TGF-ß
> inhibited Nitrite production.
>
> The therapeutic effect of IFN-ß in MS may be partly due to suppression
> of Pathogenic NO production.
>
>
>
>
>
>
>
>
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