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From: "WE MOVE" <[log in to unmask]>
Date: Wed, 26 May 2004 10:34:25 -0400
Subject: PD: New Treatment Strategies in Animal Models (AAN 2004)
Wednesday, May 26, 2004 Issue 23 VOLUME 1 ISSUE 23
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ARCHIVE
Issue 22
May 25, 2004
Vol. 1 Issue 22
Glycine-B Receptor Blockade Potentiates Levodopa (AAN 2004)
E-MOVE reports from the American Academy of Neurology, San Francisco
April 25-30, 2004. Page (A), session (S) and poster (P) numbers are from
Neurology 2004;62(7), Suppl 5
Glycine-B receptor blockade amplifies levodopa responses in MPTP
parkinsonian monkeys
SM Papa, T Greenamyre
S28.001, A257
The glycine-B receptor antagonist PAMQX potentiates subtherapeutic doses
of levodopa in parkinsonian monkeys, according to this study.
[FULL STORY]
http://www.imakenews.com/wemove/e_article000263962.cfm?x=b3bFpCL,b1Qs8yH
9
AMPA and NMDA Blockade Reduces Dyskinesias (AAN 2004)
E-MOVE reports from the American Academy of Neurology, San Francisco
April 25-30, 2004. Page (A), session (S) and poster (P) numbers are from
Neurology 2004;62(7), Suppl 5
Effect of the simultaneous blockade of AMPA and NMDA receptors on
levodopa-induced dyskinesias in MPTP-lesioned primates
F Bibbiani, A Kielaite, TN Chase
S28.003, A257-258
A combination of AMPA and NMDA receptor antagonists reduces dyskinesias
more than either alone, according to this study.
Five parkinsonian monkeys received the AMPA antagonist GYKI 47261 and the
NMDA receptor antagonist amantadine alone at the lowest effective dose,
or in combination, along with levodopa. Alone, each reduced dyskinesias
by approximately 20%, while together, dyskinesias were reduced by 51%.
The authors suggest these results indicate that both receptors
independently contribute to dyskinesia pathogenesis, and that combination
therapy may be valuable in PD.
[end]
[FULL STORY]
http://www.imakenews.com/wemove/e_article000263964.cfm?x=b3bFpCL,b1Qs8yH
9
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