 |
 |
--------- Forwarded message ---------- From: "WE MOVE" <[log in to unmask]> ate: Fri, 28 May 2004 16:47:19 -0400 Subject: Rasagiline Versus Entacapone in PD (AAN 2004) Equal Effect on Off Time from Rasagiline and Entacapone (AAN 2004) E-MOVE reports from the American Academy of Neurology, San Francisco April 25-30, 2004. Page (A), session (S) and poster (P) numbers are from Neurology 2004;62(7), Suppl 5 A comparative randomised study of rasagiline versus placebo or entacapone as adjunct to levodopa in Parkinson’s disease (PD) patients with motor fluctuations (the LARGO study) O Rascol, DJ Brooks, A Melamed, W Oertel, W Poewe, F Stocchi, E Tolosa, LARGO Study Group S38.004, A346 Rasagiline and entacapone are equally effective for reduction of off time in PD, according to this study. Six hundred eighty-seven PD patients with motor fluctuations were randomized to receive placebo, rasagiline (1.0 mg once daily), or entacapone (200 mg with each levodopa dose) as adjunctive therapy. Mean daily off time at baseline was 5.6 hours, which decreased by 1.2 hours for both rasagiline and entacapone (p<0.0001 vs. placebo reduction of 0.4 hours). Mean daily dose of levodopa was reduced by 24 mg on rasagiline and 19 mg on entacapone. Frequency of adverse reactions was similar among all groups, and neither active treatment increased dyskinesia. Modest Effect on Freezing of Gait for Rasagiline (AAN 2004) E-MOVE reports from the American Academy of Neurology, San Francisco April 25-30, 2004. Page (A), session (S) and poster (P) numbers are from Neurology 2004;62(7), Suppl 5 Rasagiline treatment can improve freezing of gait in advanced Parkinson’s disease: A prospective, randomized, double-blind, placebo- and entacapone-controlled study N Giladi, O Rascol, DJ Brooks, E Melamed, WH Oertel, W Poewe, F Stocchi, E Tolosa, LARGO Study Group P04.137, A329-330 Four hundred fifty-four patients with some degree of freezing of gait (FoG) were randomized to receive rasagiline, entacapone, or placebo. Baseline mean FoG score was 12 (24 maximum). Placebo reduced FoG by 0.5 points, versus 1.2 points for rasagiline (p=0.045), and 1.1 points for entacapone (p=0.066). No strong correlation was found for FoG reduction and off time reduction. ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn