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Hi, I need some help from my fellow PWP's. I know sometimes when my meds are not working (I take 1/2 of a Sinemet 25/100 & 1 Sinemet CR 25/100 and Mirapex about every 4 hrs) or if I'm late taking them, my symptoms hit me ...move and walk very slowly, balance problems, leg dragging, hard to swallow (no tremor), the same things I've been experiencing for several years now but today i drove about 65 - 70 miles to meet a couple of old high school buddies for breakfast and a visit, not unusual-I make a lot of road trips by myself and some 3 or 4 hrs each way. On the way home I felt like my drugs had not "kicked in" and all of a sudden I noticed it was very difficult to drive, my Land Rover was veering off the road and my arms felt like they wouldn't work... it took all the effort I could give to get the car back in the lane. O.K. so time to pull over, I stopped and got gas, drank a Pepsi, went to the bathroom and wasted as much time as I could then started off again but it was very difficult to drive when my body was working in such slow motion. I made it home O.K. but it leaves me with some questions. Does there come a time when you can't drive anymore and if so how do you know when? I am working full-time still although that too is becoming very difficult. Is it just a progression of the disease and do others have problems like this? Surely its not just me. Maybe I just need more meds or adjustment of meds? I know this is all things to ask my Neuro and I will on my next appt in July but I wanted to hear from you first. Thanks. I appreciate you all and I too, have missed Murray lately. Diane ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn