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Cambridge Opens Embryo Stem Cell Center

Mon Jun 21, 9:02 AM ET

By JANE WARDELL, Associated Press Writer

LONDON - Cambridge University is opening a center for human embryonic
stem cell research to develop treatments for currently incurable diseases
such as diabetes and spinal cord injuries.

Researchers at the $30 million Stem Cell Institute, described as the
world's largest center for this research, said Monday that they hope to
proceed to human testing within five years.

Roger Pedersen, professor of regenerative medicine at the university,
said the institute will use state of the art robotics to speed up its
research.

"The mission is to deliver clinical benefits at the earliest possible
date," Pedersen said.

Stem cells are master cells that turn into every kind of human tissue,
and scientists believe they could be used to replace diseased cells in
people suffering from spinal cord injury, diabetes, Parkinson's disease
and other ailments.

Pedersen was formerly at the University of California, San Francisco, but
left in 2001 after President Bush (news - web sites) banned federally
funded laboratories from doing research that involved the creation of any
type of human embryo.

In contrast, Britain was the first nation to authorize the cloning of
human embryos to produce stem cells for research. Last month, it opened
the world's first national stem cell bank, which stores human embryonic
stem cells among others.

Human embryonic stem cells, while controversial, are considered important
by scientists because they can form all the cells in the body. Other
types of stem cells are limited in their capacity — blood stem cells can
only form blood, for example.

"The coordinated effort on the part of the U.K. stem cell enterprise sets
the U.K. aside as the place to do this research," Pedersen said. "It
really makes the U.K. the leading country."

Pedersen said that research on stem cells is likely to lead to innovative
cell transplantation therapies and a greater understanding of the
regenerative capacity of the body.

"Stem cell research has a profound potential for treating currently
debilitating diseases, such late-onset conditions as Parkinson's,
Alzheimer's, diabetes, cancers, heart and blood diseases, and thus has
the capacity to markedly improve the quality of life," he said.

Pedersen said the Cambridge institution will first undertake a deeper
study of stem cells to increase understanding of their ability to become
other body organs before tackling clinical trials.

The center will initially target juvenile diabetes and Parkinson's
disease. Researchers selected those two diseases because both can be
treated by injections of purified stem cells of just one type.

For diabetes, insulin-producing cells could be injected anywhere in the
body and perhaps work for years. For Parkinson's disease, cells that
produce dopamine — the missing substance — would have to be injected
precisely into the brain but could help people walk and talk normally
again.

The institute is backed by the Juvenile Diabetes Foundation and other
charities as well as government funds.
The National Institute for Biological Standards and Control created last
month stores and grows cells for distribution to researchers worldwide.
The database is intended to enable fast research and ensure that all stem
cells come from ethical sources.

It currently has two human embryonic stem cell lines — collections of
identical cells — and will also accept stem cells from fetal and adult
sources.

http://news.yahoo.com/news

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