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Mucuna pruriens in Parkinson's disease: A double-blind clinical and pharmacological study R Katzenschlager, A Evans, A Manson, PN Patsalos, N Ratnaraj, H Watt, L Timmermann, R Van de Giessen, AJ Lees P710, S249 Levodopa-containing seed powder from Mucuna pruriens (cowhage, velvet bean, atmagupta) produces a rapid-onset symptomatic treatment for Parkinson's disease, according to this study. Eight patients with dyskinesias were randomized to receive either 200 mg levodopa or 15 or 30 mg M. pruriens followed by crossover. Onset of effect for the 30 mg dose was 34.6 minutes, vs. 68.5 minutes for levodopa (p = 0.021). Mean on time was 22% longer and area under the curve was 165% larger. No differences were seen in dyskinesias as assessed by two blinded video raters. ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn