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Wonderful to see you posting again, Murray! Ted and Carole ----- Original Message ----- From: "Murray Charters" <[log in to unmask]> To: <[log in to unmask]> Sent: Wednesday, July 21, 2004 2:58 AM Subject: Mucuna pruriens in Parkinson?s disease > Article from WE MOVE () > July 19, 2004 > H. pylori Eradication, Seed Powder Treatment > E-MOVE reports from the Eight International Congress of Parkinson's Disease and > Movement Disorders, Rome June 14-17, 2004. Page (S) and poster (P) numbers > are from Movement Disorders 2004;19 (suppleme > > > 1. Long-term effects of Helicobacter pylori eradication on L-Dopa absorption in > Parkinson's disease patients > L Brusa, A Pietroiusti, M Pierantozzi, S Galati, E Fedele, P Stanzione > P1133, S387 > > Eradication of Helicobacter pylori improves levodopa pharmacokinetics, according > to this study. > > Twenty-five patients with H. pylori infection and unsatisfactory levodopa response > received placebo followed by either H. pylori eradication therapy or antioxidant > therapy with allopurinol. Pharmacokinetic, clinical, and histological response was > gauged at 2 weeks and 3 months after treatment. Compared to placebo and > allopurinol, eradication therapy increased levodopa C-max and area under the > curve, with maximal benefits at 3 months, correlated with improvements in gastritis > and duodenitis. > > The authors suggest that testing for and treatment of infection in PD patients with > motor fluctuations may be beneficial. > > 2. Mucuna pruriens in Parkinson's disease: A double-blind clinical and > pharmacological study > R Katzenschlager, A Evans, A Manson, PN Patsalos, N Ratnaraj, H Watt, L > Timmermann, R Van de Giessen, AJ Lees > P710, S249 > > Levodopa-containing seed powder from Mucuna pruriens (cowhage, velvet bean, > atmagupta) produces a rapid-onset symptomatic treatment for Parkinson's disease, > according to this study. > > Eight patients with dyskinesias were randomized to receive either 200 mg levodopa > or 15 or 30 mg M. pruriens followed by crossover. Onset of effect for the 30 mg > dose was 34.6 minutes, vs. 68.5 minutes for levodopa (p = 0.021). Mean on time > was 22% longer and area under the curve was 165% larger. No differences were > seen in dyskinesias as assessed by two blinded video raters. > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn