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Article from WE MOVE () July 19, 2004 H. pylori Eradication, Seed Powder Treatment E-MOVE reports from the Eight International Congress of Parkinson’s Disease and Movement Disorders, Rome June 14-17, 2004. Page (S) and poster (P) numbers are from Movement Disorders 2004;19 (suppleme 1. Long-term effects of Helicobacter pylori eradication on L-Dopa absorption in Parkinson’s disease patients L Brusa, A Pietroiusti, M Pierantozzi, S Galati, E Fedele, P Stanzione P1133, S387 Eradication of Helicobacter pylori improves levodopa pharmacokinetics, according to this study. Twenty-five patients with H. pylori infection and unsatisfactory levodopa response received placebo followed by either H. pylori eradication therapy or antioxidant therapy with allopurinol. Pharmacokinetic, clinical, and histological response was gauged at 2 weeks and 3 months after treatment. Compared to placebo and allopurinol, eradication therapy increased levodopa C-max and area under the curve, with maximal benefits at 3 months, correlated with improvements in gastritis and duodenitis. The authors suggest that testing for and treatment of infection in PD patients with motor fluctuations may be beneficial. 2. Mucuna pruriens in Parkinson’s disease: A double-blind clinical and pharmacological study R Katzenschlager, A Evans, A Manson, PN Patsalos, N Ratnaraj, H Watt, L Timmermann, R Van de Giessen, AJ Lees P710, S249 Levodopa-containing seed powder from Mucuna pruriens (cowhage, velvet bean, atmagupta) produces a rapid-onset symptomatic treatment for Parkinson’s disease, according to this study. Eight patients with dyskinesias were randomized to receive either 200 mg levodopa or 15 or 30 mg M. pruriens followed by crossover. Onset of effect for the 30 mg dose was 34.6 minutes, vs. 68.5 minutes for levodopa (p = 0.021). Mean on time was 22% longer and area under the curve was 165% larger. No differences were seen in dyskinesias as assessed by two blinded video raters. ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn