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On 23 Jul 2004 at 14:23, M.Schild wrote:

> isn´t it the basis of Zandopa, the indian ´equivalent´ of Sinemet?
> Mucuna pruriens does contains ldopa, nobody will doubt that so it
> should be of some use. Years ago it only came in powder form and
> tasted pretty bad. Nowadays it comes in gelules so at least, bad taste
> is not a problem any more. I don´t know what the equivalence with
> regular sinemet is but people who have taken it said at least the
> constipation was no more a problem... It is a natural product so who
> will finance research? maryse

Just because a product is "natural" does not make it better.  Digitalis, for
example, is a natural substance which was used to treat heart disease because
of the alkaloids within the leaf of the foxglove (Digitalis) plant.

 Standardizing the dosage, however, was a problem with the leaf (believe it or
not, the standard back in the early to mid-20th century was to calculate how
much of the leaf extract would make a pigeon vomit!), and once the pure
alkaloids were extracted (Digitoxin, Digoxin, Gitaligin, etc.), the dosage
could be standardized.

There may be dopaminergic chemicals in mucuna (there are some in fava
beans, as well), but use of these "natural" products has many pitfalls due to
dosage considerations.

In general, give me the "pure" or synthesized product any time, especially
when dealing with drugs that have a critical dosage.


Best,

Bob

Robert A. Fink, M. D., F.A.C.S., P. C.
Neurological Surgery
2500 Milvia Street  Suite 222
Berkeley, CA  94704-2636  USA
510-849-2555     FAX: 510-849-2557
<http://www.rafink.com/>
"Ex Tristitia Virtus"

Disclaimer:  That which is written in my e-mail is not to be
considered as "medical advice".  Such advice can only be
given after a formal, in-person, consultation between
doctor and patient.

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