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Image Guided Neurologics Announces The World's First Interventional MRI Guided
Deep Brain Stimulator Implant

MELBOURNE, Fla./EWORLDWIRE/July 13, 2004 --- Image Guided Neurologics
Inc. of Melbourne is pleased to announce the world's first interventional MRI-guided
deep brain stimulator implants, performed by a neurosurgical team at UCSF Medical
Center in San Francisco. These implantations utilized a patented guidance and
delivery technology, the NEXFRAME(TM) by IGN, and they were supported by the
Philips Gyroscan Intera by Philips Medical Systems BV.

Interventional MRI, or 'iMRI,' is a technology used to image inside a patient during
surgery. Conventional MRI scanners are used to image inside a patient for
diagnoses and evaluations of medical conditions. The NEXFRAME by IGN adds the
ability within an iMRI to align to a desired target location anywhere in the brain, and
to deliver a deep brain stimulator electrode to that specific brain target with a high
degree of accuracy. Deep brain stimulation is a promising surgical treatment for
Parkinson's disease and other movement disorders.

The traditional surgical approach to implanting the neurostimulating electrode
involves placing a stereotactic head frame on a patient to serve as a platform for
guiding the electrode to the target deep within the brain. This stereotactic head
frame is a cumbersome device that is pinned to the patient's skull and is often
considered the most uncomfortable portion of the procedure. The NEXFRAME by
IGN replaces the comparably heavy frame with a small disposable guidance device
that attaches directly to the skull during surgery.

Unlike traditional deep brain stimulation surgery performed with the patient awake,
the NEXFRAME technique is performed with the patient under general anesthesia.
This greatly enhances patient comfort and safety. Also, the iMRI allows the surgeon
to image the brain as the NEXFRAME is aligned to the target within the brain. The
portion of the brain that is intended for stimulation by the electrode is about the size
of a large pea and is situated deep within the brain. Using iMRI targeting allows the
surgeon to see where the electrode will be delivered before insertion, to follow the
electrode as it is advanced, and to verify the electrode location once it is in place.

The iMRI technique is under development and could allow improvement upon the
current microelectrode-guided approach. The NEXFRAME by IGN is a promising
technology for "real time" imaging of anatomical targets within the brain.

For more information on Parkinson's Disease and deep brain stimulator surgery,
see the UCSF Neurosurgery web page at:

http://neurosurgery.medschool.ucsf.edu/patient_care/movement.html

For more information on the NEXFRAME(TM) and IGN please see the IGN web
site:

http://www.igneurologics.com

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CONTACT:
Sandy Felgar
Image-Guided Neurologics
2290 W. Eau Gallie Blvd.
Melbourne, FL 32935
PHONE. 321-309-8218
EMAIL: [log in to unmask]
http://www.igneurologics.com

KEYWORDS: neurosurgery, frameless, image-guided, DBS, deep brain stimulation,
neurostimulation, parkinson's, essential tremor, dystonia, navigus, nexframe,
nexdrive, MRI, Ucsf , iMRI

SOURCE: Image-Guided Neurologics

AVAILABLE MEDIA:

   Photo: iMRI1 (size: 23.0 k)
   iMRI Targeting
   http://newsroom.eworldwire.com/media_uploads/press51_caption.jpg

   Photo: iMRI2 (size: 32.0 k)
   Electrode implanted in targeted section of brain.
   http://newsroom.eworldwire.com/media_uploads/press52_caption.jpg

SOURCE: eworldwire
http://newsroom.eworldwire.com/wr/071304/10435.htm

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