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Bob I do not have experience with ssnri's but I think the name is a contradiction since "selective" I think refers to the fact that they only act on the seratonin system in the brain. SSRI's include Prozac, Zoloft, and Paxil. Both Seratonin and norepinepherine(or the lack thereof) in the synaptic cleft- (the area between neurons where transmission of the signal from cell to cell occurs) are thought to have a role in the development of depression. But they are found in many areas of the brain and therefor may affect other things besides mood. , The SSRI's work by blocking the reuptake of seratonin in seritonergic neurons, That is it blocks the taking up by the pre synaptic neuron of the seratonin thereby increasing the amount of seratonin in the synaptic cleft.. Other older drugs like the tricyclic antidepressants did the same thing and I wonder if research is going backwards and discovering the benefits of the norepinepherine(or reuptake blockade like pain relief which had been known for years with tricyclics I am sorry I am being aa little over technical. .I don't know any other way to describe .the function of SSRI's though without resorting to drawings. It is a situation where one picture is worth a thousand words. Charlie Bob Martone wrote: >Has any one had any experience with Selective Serotonin Norepinephrine >Reuptake Inhibitor? > >There is a new antidepressant out that also has some pain management >qualities called Cymbalta. > >I am seeking a layman's understanding on what an SSNRI is and what >reuptake inhibitor actually means. > >It appears to me from what I have recently read that this may be a >beneficial PD medication. > > > >Bob Martone > > > > >---------------------------------------------------------------------- >To sign-off Parkinsn send a message to: mailto:[log in to unmask] >In the body of the message put: signoff parkinsn > > > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn