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hi wendy, i am new to the list and haven't seen your previous posts - it is good to know i am not the only one disturbed by this. levodopa being held up as the standard against which other therapies (at least the brain surgery therapies) are judged is troubling to me because it means that if something almost measures up, but not quite, the study may be deemed a failure, the therapy may be dropped, and levodopa and dyskinesia remain the *best* therapy, rather than another option that *doesn't cause dyskinesia* being made available. does anyone know whether, in clinical trials, participant satisfaction is taken into account in the judging of the success/failure of the trial, and if so, to what degree? mackenzie --- Wendy Siegel <[log in to unmask]> wrote: > That is the point I was trying to make. Thanks for > putting it so > clearly! > > Wendy > > -----Original Message----- > What I would like to know is, given that there is a > 30% chance of > developing dyskinesia after two years of levodopa > therapy, and a 50% > chance after five years of levodopa therapy, is > anyone else disturbed by > levodopa being held up as the "best" treatment for > PD, the treatment > that must be surpassed (by therapies requiring brain > surgery, at least) > in order for them to be considered successful? > > If you were given a choice between 5 years of > levodopa-level symptom > relief with a 50% chance of having developed > dyskinesias by the end of > that period, and 5 years and maybe more of somewhat > less than > levodopa-level symptom relief, with the risks of > brain surgery but > *without* the risk of dyskinesias, which would you > choose? > > free storage! > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > __________________________________ Do you Yahoo!? Y! Messenger - Communicate in real time. Download now. http://messenger.yahoo.com ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn