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That is the point I was trying to make. Thanks for putting it so clearly! Wendy -----Original Message----- What I would like to know is, given that there is a 30% chance of developing dyskinesia after two years of levodopa therapy, and a 50% chance after five years of levodopa therapy, is anyone else disturbed by levodopa being held up as the "best" treatment for PD, the treatment that must be surpassed (by therapies requiring brain surgery, at least) in order for them to be considered successful? If you were given a choice between 5 years of levodopa-level symptom relief with a 50% chance of having developed dyskinesias by the end of that period, and 5 years and maybe more of somewhat less than levodopa-level symptom relief, with the risks of brain surgery but *without* the risk of dyskinesias, which would you choose? free storage! ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn