New Reports of Positive Preclinical Results using Small Molecule Hedgehog Agonists BIOWIRE2K CAMBRIDGE, Mass.--(BUSINESS WIRE)--Oct. 25, 2004-- Abstracts presented at annual neuroscience meeting demonstrate efficacy in models of stroke, Parkinson's disease, and spinal cord injury Curis, Inc. (NASDAQ: CRIS), a therapeutic drug development company, today announced that three new studies on small molecule Hedgehog pathway agonists are being presented at the 34th annual meeting of the Society for Neuroscience being held in San Diego, California, from October 23-27. These studies report positive results in preclinical models of stroke, Parkinson's disease, and spinal cord injury upon treatment with small molecule activators of the Hedgehog signaling pathway. The Hedgehog signaling pathway regulates the normal development of the brain and spinal cord. Curis has identified and developed several promising small molecule compounds that can activate the Hedgehog signaling pathway and thereby promote nervous system repair. These small molecules are orally available and can enter into the brain and spinal cord, thus making them a very attractive new class of drug development candidates for neurological disorders. In January 2004, Curis entered into an agreement to license Hedgehog pathway agonist technologies to Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE) on an exclusive worldwide, royalty-bearing basis. The agreement provides for the development and commercialization of pharmaceutical products based on these technologies for therapeutic applications in treatment of neurological disorders, such as stroke, Parkinson's disease, spinal cord injury, and other disorders. Dr. Lee Rubin, Curis' Chief Scientific Officer, commented, "Curis' success in discovering small molecules that can stimulate the Hedgehog signaling pathway has provided a significant opportunity to develop a novel class of drugs for the treatment of damaged nerve tissues. These new studies offer an excellent illustration of the potential breadth of neurological indications for which the Hedgehog agonists may have therapeutic benefit. We believe that our partnership with Wyeth will provide a very effective path forward for the clinical development of these exciting drug candidates." About Curis, Inc. Curis, Inc. is a therapeutic drug development company. The Company's technology focus is on regulatory pathways that control repair and regeneration. Curis' product development involves the use of proteins or small molecules to modulate these pathways. Curis has successfully used this technology and product development approach to produce several promising drug product candidates in the fields of kidney disease, neurological disorders, cancer, alopecia, and cardiovascular disease. For more information, please visit the Curis web site at www.curis.com. This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements about Curis' drug discovery and development programs. Such statements may contain the words "believes", "expects", "anticipates", "plans", "seeks", "estimates" or similar expressions. These forward looking statements are not guarantees of future performance and involve risks, uncertainties, assumptions and other factors that may cause Curis' actual results to be materially different from those indicated by such forward-looking statements. Actual results can be affected by a number of important factors including, among other things: adverse results in Curis' and its strategic partners' product development programs; difficulties or delays in obtaining or maintaining required regulatory approvals; Curis' ability to obtain or maintain the patent and other proprietary intellectual property protection necessary for the development and commercialization of products based on its technologies; changes in or Curis' inability to execute its realigned business strategy; the risk that Curis does not obtain the additional funding required to conduct research and development of its product candidates and execute on its business plan; unplanned cash requirements and expenditures; risks relating to Curis' ability to enter into and maintain important strategic partnerships, including its ability to maintain its current collaboration agreements with Genentech, Ortho and Wyeth; the risk that competitors will discover and develop signaling pathway-based therapeutics faster and more successfully that Curis and its collaborators are able to; and other risk factors identified in Curis' most recent Annual Report on Form 10-K, Quarterly Report on 10-Q and any subsequent reports filed with the Securities and Exchange Commission. In addition, any forward-looking statements represent the Company's views only as of today and should not be relied upon as representing its views as of any subsequent date. Curis disclaims any intention or obligation to update any of the forward-looking statements after the date of this press release whether as a result of new information, future events or otherwise. Contacts Curis, Inc. Chief Financial Officer Michael Gray, 617-503-6632 or Vice President, Corporate Communications Marc Charette, Ph.D., 617-503-6629 http://www.biospace.com/news_story.cfm?StoryID=17823620 ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn