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FROM: WiredNews

Clone Ban Unlikely to Pass Senate
By Kristen Philipkoski  |   Also by this reporter  Page 1 of 1
02:00 AM Nov. 08, 2004 PT

California may now be a haven for stem-cell research, but the federal
government is still debating the legality of some aspects of the science.


Sen. Sam Brownback (R-Kansas) and Rep. Dave Weldon (R-Florida) have
drafted bills that would outlaw therapeutic cloning -- a technique
scientists believe could be key to turning stem-cell research into cures
and treatments, but which also comes with ethical concerns.

With an infusion of Republicans in the Senate, the bill may be closer to
passing. Most of the six new Republican senators will likely vote in
favor of the bill. However, Sen.-elect Richard Burr (R-North Carolina)
has spoken out in favor of embryonic stem-cell research. And the bill has
also received surprising opposition from Republicans, including Sens.
Orrin Hatch (R-Utah) and Arlen Specter (R-Pennsylvania). Such departures
will likely leave the bill short of a majority, let alone the 60 votes
the bill would need to avoid filibuster.

"The question is whether the Democrats and stem-cell supporters among
Republicans can still hang tough," said R. Alta Charo, professor of law
and bioethics at the University of Wisconsin Law and Medical Schools.

The other question is whether filibustering the bill will be a priority
for its opponents at a time when protesting Supreme Court appointments
might overshadow therapeutic cloning.

Therapeutic cloning, also called somatic cell nuclear transfer, would not
lead to the birth of a human clone. Rather, researchers extract stem
cells from a several-days-old clone, which destroys the cloned embryo.
Opponents have at least two problems with the technology. They say it's
unethical to kill the embryo, which they believe deserves the same rights
as any walking, talking human. And, they say, it's a slippery slope
toward women carrying clones to term.

Brownback's and Weldon's legislation would outlaw therapeutic cloning in
the United States. The bills would also ban importation of any medical
products created using the technology in other countries. Punishment
would be up to 10 years in prison and a $1 million fine.

The international cloning landscape might influence Congress, said Nigel
Cameron, president of the Institute on Biotechnology and the Human Future
at the Chicago-Kent College of Law. Countries including Canada and France
banned all forms of cloning earlier this year, but the moves have not
been reported widely in the press. The United Nations has also debated
the subject for the past few years, also with little press attention.

Scientists want to study embryonic stem cells because they are the
precursor to every type of cell in the human body. One way to obtain stem
cells is from couples who donate extra embryos after in vitro
fertilization. But cloning embryos to get stem cells affords the
opportunity to study the development of specific diseases.

For example, researchers can extract stem cells from a clone created
using a skin cell from someone with multiple sclerosis. They would insert
the skin cell into an egg whose nucleus had been removed. When the embryo
grew to about 100 cells, scientists would remove stem cells, then coax
them to develop into nerve cells that will develop the disease. Watching
multiple sclerosis develop from the earliest stages could help
researchers find a way to stop the disease's progress.

Therapeutic cloning might also provide a genetically identical supply of
replacement cells for patients with diseases including Parkinson's,
diabetes or spinal cord injury.

Scientists working with stem cells are relying on the Republicans who
broke from their party to oppose the Brownback bill to stand their
ground.

"People like Orrin Hatch have such high integrity that they're not going
to change their minds just because this president puts pressure on them,"
said Irv Weissman, director of the Stem Cell Institute at the Stanford
University School of Medicine.

Some even hope that the passage of Proposition 71, which mandates $3
billion for stem-cell research in California over the next 10 years (the
federal government spent just $25 million last year), will encourage
President Bush to change his embryonic stem-cell policy, which limits
federal funding on embryonic stem cells to 22 lines approved by the NIH.

"(Proposition 71) is quite an important signal, which hopefully people in
Washington will see and recognize," said Rudolf Jaenisch, a researcher at
the Whitehead Institute for Biomedical Research and a biology professor
at the Massachusetts Institute of Technology.

If the president changed his position, he wouldn't have a lot to lose
since he has no more elections to win. Still, some doubt he'll budge.

"Bush is entirely willing to let patients die rather than abandon his
symbolic acts of respect for embryos (symbolic because funding does not
affect the number of embryos destroyed each year)," said Charo, the
University of Wisconsin professor, referring to the fact that in vitro
fertilization clinics often discard embryos not used by couples.

"He won't change the policy," Weissman said. "He's been very clear. I
wish he would for the first time listen to both sides of the issue,
because he's never done that."

http://www.wired.com/news/medtech/0,1286,65617,00.html?tw=wn_tophead_1

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