Hi
This is good news!
However, I should say one should proceed with caution, specially with
regard to the quantity one can take. Very high amount may cause some
problems eg. kidney problems. I also heard that for some people, turmeric
does not agree with their digestive system. In such cases, I would think a
slow increase in dose, starting with negligible amount for a few weeks or
even months and then slowly increasing the dose to an accetable level might
do the trick.
I shall post another update on this in a few weeks.
Good Luck!
Raj
*************
----- Original Message -----
From: Carole K. Menser <[log in to unmask]>
To: <[log in to unmask]>
Sent: Monday, January 31, 2005 8:09 PM
Subject: Re: In Praise of Turmeric
> Hello all --
> Well, it might just be a coincidence but we tried the Turmeric in some
Green
> Tea today and the PD pain was entirely gone in about 30 minutes. He did
not
> take any pain medication (Ibuprofen) or additional PD meds. We went to
the
> grocery and bought Tumeric in the spice isle since we couldn't get to the
> health food store today. Tomorrow we will go there for some Curcumin in
> capsule form. We used about 1/3 of a tsp. in the tea with a little honey.
> It doesn't taste bad at all. As we said, perhaps this is just a
coincidence
> but we will keep you posted.
>
> Carole and Ted (57/45/40)
>
>
> ----- Original Message -----
> From: "Brightline" <[log in to unmask]>
> To: <[log in to unmask]>
> Sent: Sunday, January 30, 2005 2:02 PM
> Subject: In Praise of Turmeric
>
>
> > Hello Everybody:
> > In my daily ritual of search for a way out of pain caused by my PD,
I
> found out to my pleasant surprise, that Curcumin or the component of
common
> Turmeric (Curcuma longa) is a potent anti-inflammatoyr activity, more
> potent than ibuprophen and naxopren (?), the popular Non-steroidal
> anti-inflammatory drugs or NSAIDs. Curcumin also inhibits Cox-2 enzyme
which
> is involved in the progression of PD and also in cancer growth. This is
> probably one of the most safe and natural NSAID one can hope for. I am
> thinking of discontinueing Celebrex and try Turmeric instead for the next
> few weeks.
> > To day I tried Sage tea with a pinch of tumeric and cinnamon added
to
> it + some sugar to taste. My muscle pain disappeared within half an hour.
> Sage is also good for the nerves. Cinnamon has anti-infection property and
> also good for people with high blood presssure and diabetes.
> > In addition, curcumin also clears amyloid aggregation in Alzheimer
> Disease. Please see the abstract given below. This also helps in
> cognizance, a problem often met in older PD patients.
> > I just thought I should share this info with you. If anybody wants
to
> try turmeric, I would like to hear their experience.
> > Have a nice day!
> > Raj
> > ************
> > Curcumin inhibits formation of ABeta oligomers and fibrils, bindsplaques
> and reduces amyloid in vivo
> > by Yang et al., J Biol Chem papers in press. Published Dec 7 2004.
> >
> > Abstract:
> > Alzheimer's disease (AD) involves amyloid (ABeta) accumulation,
> oxidative damage and inflammation; and risk is reduced with increased
> anti-oxidant and anti-inflammatory consumption. The phenolic yellow curry
> pigment curcumin has potent anti-inflammatory and antioxidant activities
and
> can suppress oxidative damage, inflammation, cognitive deficits, and
amyloid
> > accumulation. Since the molecular structure of curcumin suggested
> potential Abeta-binding, we investigated whether its efficacy in AD models
> could be explained by effects on ABeta aggregation. Under aggregating
> conditions in vitro, curcumin inhibited aggregation (IC50 = 0.8 microM) as
> well as disaggregated fibrillar Abeta40 (IC50 = 1 microM), indicating
> favorable stoichiometry for inhibition. Curcumin was a better abeta40
> aggregation inhibitor than ibuprofen and naproxen, and prevented Abeta42
> oligomer formation and toxicity between 0.1-1.0 microM. under electron
> microscopy, curcumin decreased dose-dependently Abeta fibril formation
> beginning with 0.125 microM. Curcumin's effects did not depend on Abeta
> sequence but on fibril-related conformation. AD and Tg2576 mice brain
> sections incubated with curcumin revealed preferential labeling of amyloid
> plaques. in vivo studies showed that curcumin injected peripherally into
> aged Tg mice,
> > > crossed the blood brain barrier and bound plaques. When fed to aged
> Tg2576 mice with advanced amyloid accumulation, curcumin labeled plaques
and
> reduced amyloid levels and plaque burden. hence, curcumin directly binds
> small beta-amyloid species to block aggregation and fibril formation in
> vitro and in vivo. These data suggest that low dose curcumin effectively
> > > disaggregates Abeta as well as prevents fibril and oligomer formation,
> supporting the rationale for curcumin use in clinical trials preventing or
> treating AD.
> >
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