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Raj - Here in Houston, we have a pharmacist who is more inclined to natural meds to help people. He writes for the Houston Chronicle. One day he wrote a nice informative article about the components of tumeric or cumin and how it helps arthritis. I haven't tried it yet, but I'm getting close to needing to try it. Best to you. Jo Ann On Sun, 30 Jan 2005 18:02:15 -0400 Brightline <[log in to unmask]> writes: > Hello Everybody: > In my daily ritual of search for a way out of pain caused by my > PD, I found out to my pleasant surprise, that Curcumin or the > component of common Turmeric (Curcuma longa) is a potent > anti-inflammatoyr activity, more potent than ibuprophen and naxopren > (?), the popular Non-steroidal anti-inflammatory drugs or NSAIDs. > Curcumin also inhibits Cox-2 enzyme which is involved in the > progression of PD and also in cancer growth. This is probably one > of the most safe and natural NSAID one can hope for. I am thinking > of discontinueing Celebrex and try Turmeric instead for the next few > weeks. > To day I tried Sage tea with a pinch of tumeric and cinnamon > added to it + some sugar to taste. My muscle pain disappeared within > half an hour. Sage is also good for the nerves. Cinnamon has > anti-infection property and also good for people with high blood > presssure and diabetes. > In addition, curcumin also clears amyloid aggregation in > Alzheimer Disease. Please see the abstract given below. This also > helps in cognizance, a problem often met in older PD patients. > I just thought I should share this info with you. If anybody > wants to try turmeric, I would like to hear their experience. > Have a nice day! > Raj > ************ > Curcumin inhibits formation of ABeta oligomers and fibrils, > bindsplaques and reduces amyloid in vivo > by Yang et al., J Biol Chem papers in press. Published Dec 7 2004. > > Abstract: > Alzheimer's disease (AD) involves amyloid (ABeta) accumulation, > oxidative damage and inflammation; and risk is reduced with > increased anti-oxidant and anti-inflammatory consumption. The > phenolic yellow curry pigment curcumin has potent anti-inflammatory > and antioxidant activities and can suppress oxidative damage, > inflammation, cognitive deficits, and amyloid > accumulation. Since the molecular structure of curcumin suggested > potential Abeta-binding, we investigated whether its efficacy in AD > models could be explained by effects on ABeta aggregation. Under > aggregating conditions in vitro, curcumin inhibited aggregation > (IC50 = 0.8 microM) as well as disaggregated fibrillar Abeta40 (IC50 > = 1 microM), indicating favorable stoichiometry for inhibition. > Curcumin was a better abeta40 aggregation inhibitor than ibuprofen > and naproxen, and prevented Abeta42 oligomer formation and toxicity > between 0.1-1.0 microM. under electron microscopy, curcumin > decreased dose-dependently Abeta fibril formation beginning with > 0.125 microM. Curcumin's effects did not depend on Abeta sequence > but on fibril-related conformation. AD and Tg2576 mice brain > sections incubated with curcumin revealed preferential labeling of > amyloid plaques. in vivo studies showed that curcumin injected > peripherally into aged Tg mice, > > crossed the blood brain barrier and bound plaques. When fed to > aged Tg2576 mice with advanced amyloid accumulation, curcumin > labeled plaques and reduced amyloid levels and plaque burden. > hence, curcumin directly binds small beta-amyloid species to block > aggregation and fibril formation in vitro and in vivo. These data > suggest that low dose curcumin effectively > > disaggregates Abeta as well as prevents fibril and oligomer > formation, supporting the rationale for curcumin use in clinical > trials preventing or treating AD. > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn