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Alison, You will probably receive conflicting responses to your question, since a combination of drugs that works for one person may not work for another. In my case I was taking Comtan, Sinemet, Requip and Provigil. My off-time exceeded my on-time by a wide margin. I decided it was time to change Neurologists. I am currently taking Stalevo, Requip and Amantadine, and now my on-time far exceeds any off-time. I have learned, though, that it is important for me to take my medication at regular times, even if I'm feeling great. This advice was given to me by a LISTSERV member, I don't remember who, but I am thankful for their advice. I hope, like me, your sister shows improvement with her new medications. Best wishes, Gary ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn