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Gary, Thank you for your reply. Wondering if anyone else on the List had had experience with Sinemet CR prior to starting the Comtan with Sinemet and Requip or Stalevo with Requip as a means of achieving more "on-time." Alison Landes In a message dated 2/11/05 5:24:28 A.M. Eastern Standard Time, [log in to unmask] writes: Alison, You will probably receive conflicting responses to your question, since a combination of drugs that works for one person may not work for another. In my case I was taking Comtan, Sinemet, Requip and Provigil. My off-time exceeded my on-time by a wide margin. I decided it was time to change Neurologists. I am currently taking Stalevo, Requip and Amantadine, and now my on-time far exceeds any off-time. I have learned, though, that it is important for me to take my medication at regular times, even if I'm feeling great. This advice was given to me by a LISTSERV member, I don't remember who, but I am thankful for their advice. I hope, like me, your sister shows improvement with her new medications. Best wishes, Gary In a message dated 2/10/05 8:33:20 A.M. Eastern Standard Time, Cureparkinsons writes: My sister's computer is being repaired. She asked me to submit question to ListServe about medication. She has been taking Sinemet and Requip with a lot of off time. Neurologist is going to start her on Stalevo with the Requip. She has not taken Comtan with Sinemet and Requip. Nor has she taken Sinemet CR with the Requip. Does anyone have any point of reference with the above? Thank you. Alison Landes Founder/ President Take Charge! Cure Parkinson's, Inc. 1489 W. Palmetto Park Road Suite 442 Boca Raton, Florida 33486 Tel: 561.620.1970 Fax: 561.488.5726 E-mail: [log in to unmask] Web site: _www.cureparkinsons.org_ (http://www.cureparkinsons.org/) ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn