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uh-uh -- apokyn works for the OTHER end of the symptoms; the OFF, hypomobility times; the freeze.    it would have a terrible effect if used while a PWP is at the opposite side of the spectrum, i.e., dyskentic and/or writhing.

http://www.fda.gov/bbs/topics/ANSWERS/2004/ANS01284.html

apomorphine has been available in israel for a while now, but only recently (i believe since the FDA approved it in the US) has become available in a new form of packaging which makes it user-friendly and not as off putting as "sticking a needle" might sound.   it's probably more reminiscent of the discreet insulin 'pumps' for diabetics.

and it truly works wonders to get a person out of a FREEZE.   alas, doesn't last long -- say 20 minutes or so -- but gives you enough of a window to have the next oral dose kick in.

but here's a curious (or shocking, really) thing -- had to take my israeli-american PWP who's being treated in israel, to the movement disorder center at mount sinai hospital in new york city.    you'd think, doesn't get any more cutting-edge than that.   well, surprise, surprise -- they've never seen apokyn at work!   yes, they know of its existence, but apparently the stuff is simply unavailable here.  :(  

hope this helps,

ariela

====  

> Yes, Apomorphine has been available here in the UK for several years now, I
> know two fellow sufferers of PD who used it. In both cases it did work well,
> and almost instantly, but, and it's a big but, both of these people
> experienced extreme end of dose side effects in the form of severe
> dyskenesia, uncontrollable writhing and twisting of limbs . It was  enough
> for me to regard this drug as one to avoid .
> 
> Nigel, age 50 , dx 34

> ----- Original Message -----
> From: "M.Schild" <[log in to unmask]>
> To: <[log in to unmask]>
> Sent: Tuesday, February 15, 2005 7:21 AM
> Subject: Re: APOKYN
> 
> 
> >> I HOPE EVERYONE WILL BE AS EXCITED ABOUT THIS AS I AM. ASK THEM TO SEND
> >> YOU A COPY OF THE VIDEO. IT'S GREAT. APOKYN (APOMORPHINE HYDROCHLORIDE )
> >
> >
> > It has been used in Europe for a while now.  The injections work quickly
> > but
> > the effect doesn´t last long. One can have it deliverred through the day
> > by a
> > ´pump' also
> > Maryse cg John 75,5

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