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dear hilary, just the information i'm looking for!!! what you're telling is amazing stuff! and yes, yes, i realize PD is a snowflake disease and everyone responds differently, but still, this is quite the endorsement for amantadine! you say it worked well for you for 6 years. heck, we'll take 3 years. we'll take one. sure beats DBS right now!! and re. DBS: i was under the impression the procedure worked best to alleviate tremor -- less so for rigidity, and/or dyskinesia.... ? am i off-base on this? can you, or anyone else, please stir me right? as to new stuff coming down the pike, i hear you. although personally i'm less excited about rasageline -- which is basically a variation on selegeline (or 'eldepryl'). in fact, my Big Next Hope is ROTIGOTINE which is a new receptors-agonist that most importantly has a 24-hr. delivery system -- i.e., it comes in a transdermal patch that introduces the drug into the system continuously and evenly. now THAT in itself sounds to me like a novel, sound approach! (if only the drug companies would concentrate on formulating levodopa as patch-delivered!). but regarding rotigotine, add to it the fact that for a NEW agonist, it has shown, in replicated trials, a huge statistical improvement in on/off times, and i say (to steal a line), rotigotine, do i hear you... :) thank you very much again, cheers, ariela ==== > Ariela, > > About six years ago,, my dyskinesia became so bad that I volunteered > for DBS surgery - then still in the pre-trial phase. But before my > turn came, I read on this list about someone who took amantadine > and how it almost miraculously cured his dyskinesia. I persuaded my > doctor to let me try it, and within 24 hours I no longer matched the > requirements for volunteering for the DBS trial! > > Now, 6 years later, it is losing its effect, and I am left with > increasing dyskinesias and dystonias. I have taken every PD > medication that there is, and the best response was with amantadine. > Until recently I was taking eldepryl too, but that seemed to lose its > effect, so I am sticking to my sinemet and amantadine and eagerly > waiting to see what is new coming down the pipeline. (Rasagaline, do I > hear you?) > > hilary blue > ==== > > ariela wrote: > > >rick, > > > >a new movement disorder neurologist we've now been seeing at mount sinai in new york has told us that amantadine is the drug of choice for dealing with dyskinesia. it's the first i hear this take about this little-used drug.... but we're still keeping this option open as my PWP is now trying stalevo (after 4 years on sinemet + requip). he's having an awful time just getting calibrated -- he moves instantaneously between long and painful freezes to awful states of badly spastic dyskinesia. there's just never a simple 'quiet,' 'calibrated' time. it goes without saying that the dosages and frequency have been tweaked and re-tweaked, to not much avail... :( > > > >does it sound familiar to you, or anyone on the list? can anyone please share what you do/have done/know about it? ( > > > >many thanks, > >ariela > > > >==== > > > >>But I just figure it might be worth a little extra pain in order to put off those nasty > >>diskenesias.... > >> > >>Enjoy! > >>Rick McGirr ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn