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NEUROLOGY 2005;64:1047-1051

2005 American Academy of Neurology



Consumption of milk and calcium in midlife and the future risk of Parkinson
disease



Address correspondence and reprint requests to Dr. R.D. Abbott, Department
of Health Evaluation Sciences, University of Virginia Health System, PO Box
800717, Charlottesville, VA 22908-0717; e-mail: [log in to unmask]



Objective: To examine the relation between milk and calcium intake in
midlife and the risk of Parkinson disease (PD).



Methods: Findings are based on dietary intake observed from 1965 to 1968 in
7,504 men ages 45 to 68 in the Honolulu Heart Program. Men were followed for
30 years for incident PD.



Results: In the course of follow-up, 128 developed PD (7.1/10,000
person-years). Age-adjusted incidence of PD increased with milk intake from
6.9/10,000 person-years in men who consumed no milk to 14.9/10,000
person-years in men who consumed >16 oz/day (p = 0.017). After further
adjustment for dietary and other factors, there was a 2.3-fold excess of PD
(95% CI 1.3 to 4.1) in the highest intake group (>16 oz/day) vs those who
consumed no milk. The effect of milk consumption on PD was also independent
of the intake of calcium. Calcium from dairy and nondairy sources had no
apparent relation with the risk of PD.



Conclusions: Findings suggest that milk intake is associated with an
increased risk of Parkinson disease. Whether observed effects are mediated
through nutrients other than calcium or through neurotoxic contaminants
warrants further study.








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